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L1CAM Immunopositivity in Anaplastic Supratentorial Ependymomas: Correlation With Clinical and Histological Parameters.
Chavali, Pooja; Rao, Shilpa; Palavalasa, Sravya; Bevinahalli, Nandeesh; Muthane, Yasha T C; Sadashiva, Nishanth; Santosh, Vani.
Afiliación
  • Chavali P; 1 National Institute of Mental Health and Neurosciences, Bangalore, India.
  • Rao S; 1 National Institute of Mental Health and Neurosciences, Bangalore, India.
  • Palavalasa S; 1 National Institute of Mental Health and Neurosciences, Bangalore, India.
  • Bevinahalli N; 1 National Institute of Mental Health and Neurosciences, Bangalore, India.
  • Muthane YTC; 1 National Institute of Mental Health and Neurosciences, Bangalore, India.
  • Sadashiva N; 1 National Institute of Mental Health and Neurosciences, Bangalore, India.
  • Santosh V; 1 National Institute of Mental Health and Neurosciences, Bangalore, India.
Int J Surg Pathol ; 27(3): 251-258, 2019 May.
Article en En | MEDLINE | ID: mdl-30251576
Supratentorial ependymomas (ST EPNs) are molecularly characterized, of which the RELA fusion positive tumors are the most common and aggressive subgroup. Moreover, histologically, anaplastic ST EPN (ST-AE) often mimic other central nervous system primary high-grade tumors resulting in a diagnostic dilemma. We aimed to study a cohort of ST-AE; evaluate the expression of two RELA fusion-associated markers-L1CAM and p65 (NF-κB); and correlate their expression with clinical and histological parameters. Cases of ST-AE diagnosed in our department from January 2011 to June 2016 (n = 72) were reviewed. A battery of immunohistochemical markers was employed. A total of 65 confirmed ST-AE were included in the study. Age ranged from 9 months to 60 years. There was a slight predominance in the pediatric population (57%). Male-to-female ratio was 1:1.16. Histomorphological features were varied and mimicked other high-grade tumors in several cases. L1CAM immunopositive tumors constituted 26% of cases and were predominantly seen in young children, in the frontoparietal location, and exhibited clear cell morphology with calcification. A consistent pattern of L1CAM immunopositivity was noted in paired primary and recurrent tumor samples. Our study portrays the varied clinical and histomorphological spectrum of ST-AE. The study emphasizes the association of L1CAM immunopositivity with a wide spectrum of histological parameters, literature on which is scant till date. Since ST EPN-RELA are tumors with aggressive behavior, such a correlation would be clinically relevant, particularly when there is limited access to molecular testing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Supratentoriales / Biomarcadores de Tumor / Molécula L1 de Adhesión de Célula Nerviosa / Ependimoma / Factor de Transcripción ReIA Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Idioma: En Revista: Int J Surg Pathol Asunto de la revista: PATOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Supratentoriales / Biomarcadores de Tumor / Molécula L1 de Adhesión de Célula Nerviosa / Ependimoma / Factor de Transcripción ReIA Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Idioma: En Revista: Int J Surg Pathol Asunto de la revista: PATOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos