Effect of treatment on erythrocyte phosphoribosyl pyrophosphate synthetase and glutathione reductase activity in patients with primary gout.
Ann Rheum Dis
; 45(11): 941-4, 1986 Nov.
Article
en En
| MEDLINE
| ID: mdl-3024593
The activities of erythrocyte phosphoribosyl pyrophosphate (PRPP) synthetase and glutathione reductase (GTR) were studied in 26 patients with primary gout who were receiving no treatment or treatment with either allopurinol or azapropazone, and compared with the activity in a group of healthy controls. The activity of PRPP synthetase was significantly higher in the gout group and was not influenced by either drug. No significant difference in the activity of GTR was observed. The failure of either drug to suppress the increased activity of PRPP synthetase associated with gout is discussed.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fosfotransferasas
/
Triazinas
/
Alopurinol
/
Apazona
/
Ribosa-Fosfato Pirofosfoquinasa
/
Eritrocitos
/
Glutatión Reductasa
/
Gota
Límite:
Adult
/
Aged
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Ann Rheum Dis
Año:
1986
Tipo del documento:
Article
Pais de publicación:
Reino Unido