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Synaptic and intrinsic plasticity in the ventral tegmental area after chronic cocaine.
Francis, Tanner Chase; Gantz, Stephanie C; Moussawi, Khaled; Bonci, Antonello.
Afiliación
  • Francis TC; Intramural Research Program, Synaptic Plasticity Section, National Institute on Drug Abuse, US National Institutes of Health, Baltimore, MD 21224, USA.
  • Gantz SC; Intramural Research Program, Synaptic Plasticity Section, National Institute on Drug Abuse, US National Institutes of Health, Baltimore, MD 21224, USA.
  • Moussawi K; Intramural Research Program, Synaptic Plasticity Section, National Institute on Drug Abuse, US National Institutes of Health, Baltimore, MD 21224, USA; Department of Neurology, Johns Hopkins Medicine, Baltimore, MD 21205, USA.
  • Bonci A; Intramural Research Program, Synaptic Plasticity Section, National Institute on Drug Abuse, US National Institutes of Health, Baltimore, MD 21224, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry, Johns Hopkins Un
Curr Opin Neurobiol ; 54: 66-72, 2019 02.
Article en En | MEDLINE | ID: mdl-30237117
Cocaine exposure induces persistent changes in synaptic transmission and intrinsic properties of ventral tegmental area (VTA) dopamine neurons. Despite significant progress in understanding cocaine-induced plasticity, an effective treatment of cocaine addiction is lacking. Chronic cocaine potentiates excitatory and alters inhibitory transmission to dopamine neurons, induces dopamine neuron hyperexcitability, and reduces dopamine release in projection areas. Understanding how intrinsic and synaptic plasticity interact to control dopamine neuron firing and dopamine release could prove useful in the development of new therapeutics. In this review, we examine recent literature discussing cocaine-induced plasticity in the VTA and highlight potential therapeutic interventions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sinapsis / Cocaína / Área Tegmental Ventral / Inhibidores de Captación de Dopamina / Neuronas Dopaminérgicas / Plasticidad Neuronal Límite: Animals / Humans Idioma: En Revista: Curr Opin Neurobiol Asunto de la revista: BIOLOGIA / NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sinapsis / Cocaína / Área Tegmental Ventral / Inhibidores de Captación de Dopamina / Neuronas Dopaminérgicas / Plasticidad Neuronal Límite: Animals / Humans Idioma: En Revista: Curr Opin Neurobiol Asunto de la revista: BIOLOGIA / NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido