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The interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers.
Anderson-Hanley, Cay; Stark, Jessica; Wall, Kathryn M; VanBrakle, Marisa; Michel, Makenzie; Maloney, Molly; Barcelos, Nicole; Striegnitz, Kristina; Cohen, Brian D; Kramer, Arthur F.
Afiliación
  • Anderson-Hanley C; Healthy Aging & Neuropsychology Lab, Department of Psychology & Neuroscience Program, Union College, Schenectady, NY, USA, andersoc@union.edu.
  • Stark J; Healthy Aging & Neuropsychology Lab, Department of Psychology & Neuroscience Program, Union College, Schenectady, NY, USA, andersoc@union.edu.
  • Wall KM; Healthy Aging & Neuropsychology Lab, Department of Psychology & Neuroscience Program, Union College, Schenectady, NY, USA, andersoc@union.edu.
  • VanBrakle M; Healthy Aging & Neuropsychology Lab, Department of Psychology & Neuroscience Program, Union College, Schenectady, NY, USA, andersoc@union.edu.
  • Michel M; Healthy Aging & Neuropsychology Lab, Department of Psychology & Neuroscience Program, Union College, Schenectady, NY, USA, andersoc@union.edu.
  • Maloney M; Healthy Aging & Neuropsychology Lab, Department of Psychology & Neuroscience Program, Union College, Schenectady, NY, USA, andersoc@union.edu.
  • Barcelos N; Healthy Aging & Neuropsychology Lab, Department of Psychology & Neuroscience Program, Union College, Schenectady, NY, USA, andersoc@union.edu.
  • Striegnitz K; Computer Science Department & Neuroscience Program, Union College, Schenectady, NY, USA.
  • Cohen BD; Biology Department, Union College, Schenectady, NY, USA.
  • Kramer AF; Center for Cognitive & Brain Health, Department of Psychology, Northeastern University, Boston, MA, USA.
Clin Interv Aging ; 13: 1565-1577, 2018.
Article en En | MEDLINE | ID: mdl-30233154
BACKGROUND: Alzheimer's and related dementias are on the rise, and older adults and their families are seeking accessible and effective ways to stave off or ameliorate mild cognitive impairment (MCI). AIM: This pilot clinical trial (ClinicalTrials.gov Identifier: 03069391) examined neuropsychological and neurobiological outcomes of interactive physical and mental exercise. PARTICIPANTS AND METHODS: Older adults (MCI and caregivers) were enrolled in a 3-month, in-home trial of a portable neuro-exergame (the interactive Physical and Cognitive Exercise System [iPACES™]), in which they pedaled and steered along a virtual bike path to complete a list of errands (Memory Lane™). Neuropsychological function and salivary biomarkers were measured at pre-, mid-, and posttrial. Ten older adults complied with the recommended use of iPACES (complete dose; ≥2×/wk, 67% of the 15 who also had pre- and postevaluation data). Statistical analyses compared change over time and also change among those with a complete dose vs inadequate dose. Correlations between change in neuropsychological and biomarker measures were also examined. RESULTS: Executive function and verbal memory increased after 3 months (p = 0.01; no significant change was found with an inadequate dose). Change in salivary biomarkers was moderately associated with increasing cognition (cortisol, r = 0.68; IGF-1, r = 0.37). CONCLUSION: Further research is needed, but these pilot data provide preliminary indications to suggest neuro-exergaming can impact cognitive function, perhaps via neurobiological mechanisms, and as such may provide an effective and practical way to promote healthy aging.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor I del Crecimiento Similar a la Insulina / Hidrocortisona / Ejercicio Físico / Juegos de Video / Disfunción Cognitiva Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Interv Aging Asunto de la revista: GERIATRIA Año: 2018 Tipo del documento: Article Pais de publicación: Nueva Zelanda
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor I del Crecimiento Similar a la Insulina / Hidrocortisona / Ejercicio Físico / Juegos de Video / Disfunción Cognitiva Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Interv Aging Asunto de la revista: GERIATRIA Año: 2018 Tipo del documento: Article Pais de publicación: Nueva Zelanda