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Treatable traits can be identified in a severe asthma registry and predict future exacerbations.
McDonald, Vanessa M; Hiles, Sarah A; Godbout, Krystelle; Harvey, Erin S; Marks, Guy B; Hew, Mark; Peters, Matthew; Bardin, Philip G; Reynolds, Paul N; Upham, John W; Baraket, Melissa; Bhikoo, Zaheerodin; Bowden, Jeffrey; Brockway, Ben; Chung, Li Ping; Cochrane, Belinda; Foxley, Gloria; Garrett, Jeffrey; Jayaram, Lata; Jenkins, Christine; Katelaris, Constance; Katsoulotos, Gregory; Koh, Mariko S; Kritikos, Vicky; Lambert, Marina; Langton, David; Lara Rivero, Alexis; Middleton, Peter G; Nanguzgambo, Aldoph; Radhakrishna, Naghmeh; Reddel, Helen; Rimmer, Janet; Southcott, Anne Marie; Sutherland, Michael; Thien, Francis; Wark, Peter A B; Yang, Ian A; Yap, Elaine; Gibson, Peter G.
Afiliación
  • McDonald VM; Centre of Excellence in Severe Asthma and Priority Research Centre for Healthy Lungs, Faculty of Health, University of Newcastle, Callaghan, NSW, Australia.
  • Hiles SA; Centre of Excellence in Severe Asthma and Priority Research Centre for Healthy Lungs, Faculty of Health, University of Newcastle, Callaghan, NSW, Australia.
  • Godbout K; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Québec, QC, Canada.
  • Harvey ES; Centre of Excellence in Severe Asthma and Priority Research Centre for Healthy Lungs, Faculty of Health, University of Newcastle, Callaghan, NSW, Australia.
  • Marks GB; Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, NSW, Australia.
  • Hew M; South Western Sydney Clinical School, UNSW Sydney, Liverpool, NSW, Australia.
  • Peters M; Woolcock Institute of Medical Research, The University of Sydney, Glebe, NSW, Australia.
  • Bardin PG; Difficult Asthma Clinic, Allergy, Asthma and Clinical Immunology, Alfred Health, Melbourne, VIC, Australia.
  • Reynolds PN; Department of Thoracic Medicine, Concord Hospital, Concord, NSW, Australia.
  • Upham JW; Lung and Sleep Medicine, Monash University and Medical Centre, Clayton, VIC, Australia.
  • Baraket M; Department of Lung Research, Hanson Institute, Adelaide, SA, Australia.
  • Bhikoo Z; Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, SA, Australia.
  • Bowden J; The University of Queensland Diamantina Institute, Woolloongabba, QLD, Australia.
  • Brockway B; Department of Respiratory Medicine, Princess Alexandra Hospital, Woolloongabba, QLD, Australia.
  • Chung LP; Department of Respiratory Medicine, Liverpool Hospital and School of Medicine, UNSW Sydney, Liverpool, NSW, Australia.
  • Cochrane B; Respiratory Department, Waikato Hospital, Hamilton, New Zealand.
  • Foxley G; Department of Respiratory, Allergy and Sleep Medicine, Flinders Medical Centre, Bedford Park, SA, Australia.
  • Garrett J; Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
  • Jayaram L; Department of Respiratory Medicine, Fiona Stanley Hospital, Murdoch, WA, Australia.
  • Jenkins C; Department of Respiratory and Sleep Medicine, Campbelltown Hospital, Campbelltown, NSW, Australia.
  • Katelaris C; School of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
  • Katsoulotos G; Woolcock Institute of Medical Research, The University of Sydney, Glebe, NSW, Australia.
  • Koh MS; Respiratory Department, Middlemore Hospital, Auckland, New Zealand.
  • Kritikos V; Department of Medicine, Melbourne Clinical School, University of Melbourne, Melbourne, VIC, Australia.
  • Lambert M; Department of Respiratory and Sleep Disorders Medicine, Western Health, Footscray, VIC, Australia.
  • Langton D; Department of Thoracic Medicine, Concord Hospital, Concord, NSW, Australia.
  • Lara Rivero A; Concord Clinical School and Respiratory Discipline, University of Sydney, Concord, NSW, Australia.
  • Middleton PG; Respiratory Group, The George Institute for Global Health, Newtown, NSW, Australia.
  • Nanguzgambo A; Respiratory Medicine, UNSW Sydney, Liverpool, NSW, Australia.
  • Radhakrishna N; School of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
  • Reddel H; Immunology Department, Campbelltown Hospital, Campbelltown, NSW, Australia.
  • Rimmer J; St George Specialist Centre, Kogarah, NSW, Australia.
  • Southcott AM; Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.
  • Sutherland M; Duke - National University Singapore Medical School, Singapore.
  • Thien F; Woolcock Institute of Medical Research, Quality Use of Respiratory Medicines, The University of Sydney, Glebe, NSW, Australia.
  • Wark PAB; Department of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
  • Yang IA; Respiratory Services, MidCentral Health, Palmerston North Hospital, Palmerston North, New Zealand.
  • Yap E; Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, Australia.
  • Gibson PG; Department of Thoracic Medicine, Frankston Hospital, Frankston, VIC, Australia.
Respirology ; 24(1): 37-47, 2019 01.
Article en En | MEDLINE | ID: mdl-30230137
BACKGROUND AND OBJECTIVE: A new taxonomic and management approach, termed treatable traits, has been proposed for airway diseases including severe asthma. This study examined whether treatable traits could be identified using registry data and whether particular treatable traits were associated with future exacerbation risk. METHODS: The Australasian Severe Asthma Web-Based Database (SAWD) enrolled 434 participants with severe asthma and a comparison group of 102 participants with non-severe asthma. Published treatable traits were mapped to registry data fields and their prevalence was described. Participants were characterized at baseline and every 6 months for 24 months. RESULTS: In SAWD, 24 treatable traits were identified in three domains: pulmonary, extrapulmonary and behavioural/risk factors. Patients with severe asthma expressed more pulmonary and extrapulmonary treatable traits than non-severe asthma. Allergic sensitization, upper-airway disease, airflow limitation, eosinophilic inflammation and frequent exacerbations were common in severe asthma. Ten traits predicted exacerbation risk; among the strongest were being prone to exacerbations, depression, inhaler device polypharmacy, vocal cord dysfunction and obstructive sleep apnoea. CONCLUSION: Treatable traits can be assessed using a severe asthma registry. In severe asthma, patients express more treatable traits than non-severe asthma. Traits may be associated with future asthma exacerbation risk demonstrating the clinical utility of assessing treatable traits.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Manejo de Atención al Paciente / Sistema de Registros / Clasificación Tipo de estudio: Diagnostic_studies / Etiology_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Oceania Idioma: En Revista: Respirology Año: 2019 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Manejo de Atención al Paciente / Sistema de Registros / Clasificación Tipo de estudio: Diagnostic_studies / Etiology_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Oceania Idioma: En Revista: Respirology Año: 2019 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Australia