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Redox-Dependent Expression of Genes Encoding NADPH Oxidase 5 and the Key Antioxidant Enzymes during Formation of Drug Resistance of Tumor Cells to Cisplatin.
Kalinina, E V; Andreev, Y A; Petrova, A S; Lubova, K I; Shtil', A A; Chernov, N N; Novichkova, M D; Nurmuradov, N K.
Afiliación
  • Kalinina EV; Peoples' Friendship University of Russia, Moscow, Russia. elena.v.kalinina@gmail.com.
  • Andreev YA; M. M. Shemyakin and Yu. A. Ovchinnikov of Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
  • Petrova AS; Peoples' Friendship University of Russia, Moscow, Russia.
  • Lubova KI; M. M. Shemyakin and Yu. A. Ovchinnikov of Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
  • Shtil' AA; N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
  • Chernov NN; Peoples' Friendship University of Russia, Moscow, Russia.
  • Novichkova MD; Peoples' Friendship University of Russia, Moscow, Russia.
  • Nurmuradov NK; Peoples' Friendship University of Russia, Moscow, Russia.
Bull Exp Biol Med ; 165(5): 678-681, 2018 Sep.
Article en En | MEDLINE | ID: mdl-30225719
Expression of genes that plays a significant role in the control of cellular redox homeostasis was studied during the development of drug resistance of human ovarian adenocarcinoma SKOV-3 cells to cisplatin. It was found that the development of drug resistance was accompanied by enhanced expression of the genes encoding the key antioxidant enzymes (SOD2, CAT, GPX1, and HO-1) and transcription factor Nrf2, as well as reduced expression of the gene encoding NOX5 isoform of NADPH oxidase. The results testify to redox-dependent development of the adaptive antioxidant response as an important process in the mechanism of formation of resistance to cisplatin.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación Neoplásica de la Expresión Génica / Cisplatino / Resistencia a Antineoplásicos / Factor 2 Relacionado con NF-E2 / NADPH Oxidasa 5 / Antineoplásicos Límite: Female / Humans Idioma: En Revista: Bull Exp Biol Med Año: 2018 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación Neoplásica de la Expresión Génica / Cisplatino / Resistencia a Antineoplásicos / Factor 2 Relacionado con NF-E2 / NADPH Oxidasa 5 / Antineoplásicos Límite: Female / Humans Idioma: En Revista: Bull Exp Biol Med Año: 2018 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos