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A SOD2 Polymorphism is Associated with Abnormal Quantitative Sensory Testing in Type 2 Diabetic Patients.
Isikli, Ali; Kubat-Üzüm, Ayse; Satman, Ilhan; Matur, Zeliha; Öge, A Emre; Küçükali, Cem Ismail; Tüzün, Erdem; Erden, Sacide; Özkök, Elif.
Afiliación
  • Isikli A; Department of Neuroscience, Aziz Sancar Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey.
  • Kubat-Üzüm A; Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Satman I; Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Matur Z; Department of Neurology, Faculty of Medicine, Istanbul Bilim University, Istanbul, Turkey.
  • Öge AE; Department of Neurology, Faculty of Medicine, Istanbul Bilim University, Istanbul, Turkey.
  • Küçükali CI; Department of Neuroscience, Aziz Sancar Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey.
  • Tüzün E; Department of Neuroscience, Aziz Sancar Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey.
  • Erden S; Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Özkök E; Department of Neuroscience, Aziz Sancar Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey.
Noro Psikiyatr Ars ; 55(3): 276-279, 2018 Sep.
Article en En | MEDLINE | ID: mdl-30224876
INTRODUCTION: Diabetes mellitus (DM) affects peripheral nerves inducing diabetic polyneuropathy (DPN). Mitochondrial dysfunction and oxidative stress are potential causes of DPN. METHODS: Nerve conduction studies were performed in 20 type 2 DM patients (11 with DPN) and 15 healthy controls. Perception threshold values of cold, warm and vibration were measured by quantitative sensory testing. Variants of a superoxide dismutase 2 (SOD2) gene single nucleotide polymorphism (SNP) (rs5746136) were determined by polymerase chain reaction (PCR) and following NexteraXT DNA Library. RESULTS: DPN patients showed significantly increased threshold values. DM patients without DPN and healthy controls showed comparable values. TT variant of the SOD2 SNP was more prevalent in DM and DPN patients. DM patients with the TT variant displayed increased perception threshold values. CONCLUSIONS: Quantitative sensory testing is not superior to standard nerve conduction studies in DPN. Carriers of SOD2 SNP manifested increased sensory threshold levels which is important in further corroborating the link between oxidative stress and DPN.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Noro Psikiyatr Ars Año: 2018 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Turquía
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Noro Psikiyatr Ars Año: 2018 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Turquía