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Impaired Odor Perception in Autism Spectrum Disorder Is Associated with Decreased Activity in Olfactory Cortex.
Koehler, L; Fournel, A; Albertowski, K; Roessner, V; Gerber, J; Hummel, C; Hummel, T; Bensafi, M.
Afiliación
  • Koehler L; Smell & Taste Clinic, Department of Otorhinolaryngology, "Technische Universität Dresden," Fetscherstraße, Dresden, Germany.
  • Fournel A; CNRS, UMR5292, Lyon Neuroscience Research Center, University Lyon, France.
  • Albertowski K; Department of Child and Adolescent Psychiatry and Psychotherapy, "Technische Universität Dresden," Fetscherstraße, Dresden, Germany.
  • Roessner V; Department of Child and Adolescent Psychiatry and Psychotherapy, "Technische Universität Dresden," Fetscherstraße, Dresden, Germany.
  • Gerber J; Department of Neuroradiology, "Technische Universität Dresden," Fetscherstraße, Dresden, Germany.
  • Hummel C; Smell & Taste Clinic, Department of Otorhinolaryngology, "Technische Universität Dresden," Fetscherstraße, Dresden, Germany.
  • Hummel T; Smell & Taste Clinic, Department of Otorhinolaryngology, "Technische Universität Dresden," Fetscherstraße, Dresden, Germany.
  • Bensafi M; CNRS, UMR5292, Lyon Neuroscience Research Center, University Lyon, France.
Chem Senses ; 43(8): 627-634, 2018 09 22.
Article en En | MEDLINE | ID: mdl-30219913
Autism Spectrum Disorders (ASDs) are characterized by atypical sensory functioning in the visual, tactile, and auditory systems. Although less explored, olfactory changes have been reported in ASD patients. To explore these changes on a neural level, 18 adults with ASD and 18 healthy neurotypical controls were examined in a 2-phase study. Participants were first tested for odor threshold and odor identification. Then, (i) structural magnetic resonance (MR) images of the olfactory bulb were acquired, and (ii) a functional MR imaging olfaction study was conducted. ASD patients exhibited decreased function for odor thresholds and odor identification; this was accompanied by a relatively decreased activation in the piriform cortex. In conclusion, these findings suggest, that the known alterations in olfaction in ASD are rooted in the primary olfactory cortex.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Autístico / Percepción Olfatoria / Corteza Olfatoria / Odorantes Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Chem Senses Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Autístico / Percepción Olfatoria / Corteza Olfatoria / Odorantes Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Chem Senses Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido