Your browser doesn't support javascript.
loading
In Vitro Models for Studying Transport Across Epithelial Tissue Barriers.
Arumugasaamy, Navein; Navarro, Javier; Kent Leach, J; Kim, Peter C W; Fisher, John P.
Afiliación
  • Arumugasaamy N; Fischell Department of Bioengineering, University of Maryland, College Park, 4102A Clark Hall, 8278 Paint Branch Drive, College Park, MD, 20742, USA.
  • Navarro J; Center for Engineering Complex Tissues, University of Maryland, College Park, College Park, MD, 20742, USA.
  • Kent Leach J; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Health System, Washington, D.C, 20010, USA.
  • Kim PCW; Fischell Department of Bioengineering, University of Maryland, College Park, 4102A Clark Hall, 8278 Paint Branch Drive, College Park, MD, 20742, USA.
  • Fisher JP; Center for Engineering Complex Tissues, University of Maryland, College Park, College Park, MD, 20742, USA.
Ann Biomed Eng ; 47(1): 1-21, 2019 Jan.
Article en En | MEDLINE | ID: mdl-30218224
Epithelial barriers are the body's natural defense system to regulating passage from one domain to another. In our efforts to understand what can and cannot cross these barriers, models have emerged as a reductionist approach to rigorously study and investigate this question. In particular, in vitro tissue models have become prominent as there is an increased exploration of understanding biological molecular transport. Herein, we introduce the pertinent physiology, then discuss recent studies and approaches for building models of five epithelial tissues: skin, the gastrointestinal tract, the lungs, the blood-brain barrier, and the placenta. In particular, we evaluated literature from the past 5 years utilizing a tissue model to evaluate molecular transport. We then compare physiology of these tissues and discuss similarities in approaches, across tissues, to validate these models. We conclude with a summary of the approaches of growing interest across multiple tissues and an outlook on future steps to improve these models.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Epitelio / Modelos Biológicos Límite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Ann Biomed Eng Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Epitelio / Modelos Biológicos Límite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Ann Biomed Eng Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos