A versatile insulin analog with high potency for both insulin and insulin-like growth factor 1 receptors: Structural implications for receptor binding.

Chrudinová, Martina; Záková, Lenka; Marek, Ales; Socha, Ondrej; Budesínský, Milos; Hubálek, Martin; Pícha, Jan; Machácková, Katerina; Jirácek, Jirí; Selicharová, Irena

Chrudinová, Martina; Záková, Lenka; Marek, Ales; Socha, Ondrej; Budesínský, Milos; Hubálek, Martin; Pícha, Jan; Machácková, Katerina; Jirácek, Jirí; Selicharová, Irena.

Afiliación

Chrudinová M; From the Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 166 10 Prague 6, Czech Republic.
Záková L; From the Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 166 10 Prague 6, Czech Republic.
Marek A; From the Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 166 10 Prague 6, Czech Republic.
Socha O; From the Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 166 10 Prague 6, Czech Republic.
Budesínský M; From the Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 166 10 Prague 6, Czech Republic.
Hubálek M; From the Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 166 10 Prague 6, Czech Republic.
Pícha J; From the Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 166 10 Prague 6, Czech Republic.
Machácková K; From the Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 166 10 Prague 6, Czech Republic.
Jirácek J; From the Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 166 10 Prague 6, Czech Republic.
Selicharová I; From the Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 166 10 Prague 6, Czech Republic selicharova@uochb.cas.cz.

J Biol Chem ; 293(43): 16818-16829, 2018 10 26.

Article en En | MEDLINE | ID: mdl-30213860

Asunto(s)

Insulina/agonistas; Insulina/metabolismo; Receptor de Insulina/metabolismo; Receptores de Somatomedina/metabolismo; Secuencia de Aminoácidos; Cristalografía por Rayos X; Humanos; Factor I del Crecimiento Similar a la Insulina/química; Factor I del Crecimiento Similar a la Insulina/genética; Factor I del Crecimiento Similar a la Insulina/metabolismo; Cinética; Unión Proteica; Receptor IGF Tipo 1; Receptor de Insulina/química; Receptor de Insulina/genética; Receptores de Somatomedina/química; Receptores de Somatomedina/genética

Palabras clave

Site 1; binding; insulin; insulin receptor; insulin-like growth factor (IGF); kinetics; protein design; structure-function

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptor de Insulina / Receptores de Somatomedina / Insulina Límite: Humans Idioma: En Revista: J Biol Chem Año: 2018 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Estados Unidos

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