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Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease.
Teo, Shu Mei; Tang, Howard H F; Mok, Danny; Judd, Louise M; Watts, Stephen C; Pham, Kym; Holt, Barbara J; Kusel, Merci; Serralha, Michael; Troy, Niamh; Bochkov, Yury A; Grindle, Kristine; Lemanske, Robert F; Johnston, Sebastian L; Gern, James E; Sly, Peter D; Holt, Patrick G; Holt, Kathryn E; Inouye, Michael.
Afiliación
  • Teo SM; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; Department of Biochemistry and Molecular Biology
  • Tang HHF; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; School of BioSciences, The University of Melbour
  • Mok D; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia.
  • Judd LM; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia.
  • Watts SC; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia.
  • Pham K; Department of Clinical Pathology, The University of Melbourne, Parkville, VIC 3010, Australia.
  • Holt BJ; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia.
  • Kusel M; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia.
  • Serralha M; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia.
  • Troy N; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia.
  • Bochkov YA; University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
  • Grindle K; University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
  • Lemanske RF; University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
  • Johnston SL; Airway Disease Infection Section and MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK.
  • Gern JE; University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
  • Sly PD; Child Health Research Centre, The University of Queensland, Brisbane 4101, Australia.
  • Holt PG; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia; Child Health Research Centre, The University of Queensland, Brisbane 4101, Australia.
  • Holt KE; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia; The London School of Hygiene and Tropical Medicine,
  • Inouye M; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; School of BioSciences, The University of Melbour
Cell Host Microbe ; 24(3): 341-352.e5, 2018 09 12.
Article en En | MEDLINE | ID: mdl-30212648
Repeated cycles of infection-associated lower airway inflammation drive the pathogenesis of persistent wheezing disease in children. In this study, the occurrence of acute respiratory tract illnesses (ARIs) and the nasopharyngeal microbiome (NPM) were characterized in 244 infants through their first five years of life. Through this analysis, we demonstrate that >80% of infectious events involve viral pathogens, but are accompanied by a shift in the NPM toward dominance by a small range of pathogenic bacterial genera. Unexpectedly, this change frequently precedes the detection of viral pathogens and acute symptoms. Colonization of illness-associated bacteria coupled with early allergic sensitization is associated with persistent wheeze in school-aged children, which is the hallmark of the asthma phenotype. In contrast, these bacterial genera are associated with "transient wheeze" that resolves after age 3 years in non-sensitized children. Thus, to complement early allergic sensitization, monitoring NPM composition may enable early detection and intervention in high-risk children.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / Inmunoglobulina E / Nasofaringe / Microbiota Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies / Screening_studies Límite: Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Cell Host Microbe Asunto de la revista: MICROBIOLOGIA Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / Inmunoglobulina E / Nasofaringe / Microbiota Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies / Screening_studies Límite: Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Cell Host Microbe Asunto de la revista: MICROBIOLOGIA Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos