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Conservative Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw with Er,Cr:YSGG Laser and Platelet-Rich Plasma: A Longitudinal Study.
Mauceri, Rodolfo; Panzarella, Vera; Maniscalco, Laura; Bedogni, Alberto; Licata, Maria Ester; Albanese, Antonino; Toia, Francesca; Cumbo, Enzo Maria Giuseppe; Mazzola, Giuseppina; Di Fede, Olga; Campisi, Giuseppina.
Afiliación
  • Mauceri R; Department of Surgical, Oncological and Oral Sciences, Sector of Oral Medicine "V. Margiotta", University of Palermo, Palermo, Italy.
  • Panzarella V; Department of Sensor-Neural and Motor Surgery, Sector of Oral Medicine and Dentistry for Patients with Special Needs, University Hospital "Paolo Giaccone", Palermo, Italy.
  • Maniscalco L; Department of Surgical, Oncological and Oral Sciences, Sector of Oral Medicine "V. Margiotta", University of Palermo, Palermo, Italy.
  • Bedogni A; Department of Sensor-Neural and Motor Surgery, Sector of Oral Medicine and Dentistry for Patients with Special Needs, University Hospital "Paolo Giaccone", Palermo, Italy.
  • Licata ME; Department of Sensor-Neural and Motor Surgery, Sector of Oral Medicine and Dentistry for Patients with Special Needs, University Hospital "Paolo Giaccone", Palermo, Italy.
  • Albanese A; Unit of Maxillofacial Surgery, Department of Neuroscience (DNS), University of Padua, Padua, Italy.
  • Toia F; Department of Surgical, Oncological and Oral Sciences, Sector of Oral Medicine "V. Margiotta", University of Palermo, Palermo, Italy.
  • Cumbo EMG; Department of Surgical, Oncological and Oral Sciences, Sector of Oral Medicine "V. Margiotta", University of Palermo, Palermo, Italy.
  • Mazzola G; Department of Surgical, Oncological and Oral Sciences, Sector of Oral Medicine "V. Margiotta", University of Palermo, Palermo, Italy.
  • Di Fede O; Department of Surgical, Oncological and Oral Sciences, Sector of Oral Medicine "V. Margiotta", University of Palermo, Palermo, Italy.
  • Campisi G; Unit of Transfusional Medicine, University Hospital "Paolo Giaccone", Palermo, Italy.
Biomed Res Int ; 2018: 3982540, 2018.
Article en En | MEDLINE | ID: mdl-30211221
INTRODUCTION: The management of bisphosphonate-related osteonecrosis of the jaw (BRONJ), with no evidence-based guidelines, remains controversial. We aimed to evaluate the efficiency of a conservative surgical treatment combining Er,Cr:YSGG laser and platelet-rich plasma (PRP) for the treatment of BRONJ in cancer patients. METHODS: We performed a longitudinal cohort study. Inclusion criteria were (1) age ≥ 18 years; (2) cancer diagnosis; (3) treatment with NBP because of the underlying cancer. RESULTS: We consecutively recruited ten patients diagnosed with BRONJ in stage I or II. These patients underwent a surgical laser-assisted therapy together with autologous PRP. At the latest follow-up at 12 months, clinical improvement was observed in eight patients. Registration Number is IRCT20180329039159N1. CONCLUSION: We could successfully manage the BRONJ utilizing this combined protocol to heal the 30% of surgically treated sites and to improve the 50% of patients' lesions clinically. Our findings suggest that a surgical approach combined with Er,Cr:YSGG laser and PRP benefit cancer patients with general health issues.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasma Rico en Plaquetas / Láseres de Estado Sólido / Osteonecrosis de los Maxilares Asociada a Difosfonatos Tipo de estudio: Guideline / Observational_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Biomed Res Int Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasma Rico en Plaquetas / Láseres de Estado Sólido / Osteonecrosis de los Maxilares Asociada a Difosfonatos Tipo de estudio: Guideline / Observational_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Biomed Res Int Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos