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Can Plasma Rich in Growth Factors Be Safe for Parental Use? A Safety Study in the Canine Model.
Damiá, Elena; Chicharro, Deborah; Rubio, Mónica; Carrillo, José María; Sopena, Joaquín; Cuervo, Belén; López, Sergio; Vilar, José Manuel.
Afiliación
  • Damiá E; Bioregenerative Medicine and Applied Surgery Research Group, Department of Animal Medicine and Surgery, Faculty of Veterinary, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain. elena.damia@uchceu.es.
  • Chicharro D; Bioregenerative Medicine and Applied Surgery Research Group, Department of Animal Medicine and Surgery, Faculty of Veterinary, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain. debora.chicharro@uchceu.es.
  • Rubio M; Bioregenerative Medicine and Applied Surgery Research Group, Department of Animal Medicine and Surgery, Faculty of Veterinary, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain. mrubio@uchceu.es.
  • Carrillo JM; García Cugat Foundation CEU-UCH Chair of Medicine and Regenerative Surgery, 08006 Barcelona, Spain. mrubio@uchceu.es.
  • Sopena J; Bioregenerative Medicine and Applied Surgery Research Group, Department of Animal Medicine and Surgery, Faculty of Veterinary, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain. jcarrill@uchceu.es.
  • Cuervo B; García Cugat Foundation CEU-UCH Chair of Medicine and Regenerative Surgery, 08006 Barcelona, Spain. jcarrill@uchceu.es.
  • López S; Bioregenerative Medicine and Applied Surgery Research Group, Department of Animal Medicine and Surgery, Faculty of Veterinary, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain. jsopena@uchceu.es.
  • Vilar JM; García Cugat Foundation CEU-UCH Chair of Medicine and Regenerative Surgery, 08006 Barcelona, Spain. jsopena@uchceu.es.
Int J Mol Sci ; 19(9)2018 Sep 11.
Article en En | MEDLINE | ID: mdl-30208586
Low invasiveness is the main goal of modern surgery. The use of platelet-rich plasma (PRP) is known to be effective in a variety of applications, such as oral, maxillofacial, orthopedic, dermatologic and cosmetic surgeries. However, a potential ergogenic and carcinogenic effect of PRP derivatives by means of the insulin-like growth factor-1 (IGF-1) pathway has been suggested. Because of this notion, the purpose of this study is to assess the effect of a commercially available PRP-derivative intramuscular injection in the lumbar muscular tissue (local effect) and to determine the IGF-1 blood concentration (systemic effect) on healthy beagle dogs. Local effect was evaluated by computed tomography (CT) scan and echography, and systemic effect was calculated by blood testing on days 0, 14, 28, 42 and 56. No statistically significant changes were observed; thus, PRGF could be considered safe when using therapeutic doses.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor I del Crecimiento Similar a la Insulina / Plasma Rico en Plaquetas Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Int J Mol Sci Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor I del Crecimiento Similar a la Insulina / Plasma Rico en Plaquetas Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Int J Mol Sci Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza