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The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase.
Mori, Giorgia; Orena, Beatrice Silvia; Franch, Clara; Mitchenall, Lesley A; Godbole, Adwait Anand; Rodrigues, Liliana; Aguilar-Pérez, Clara; Zemanová, Júlia; Huszár, Stanislav; Forbak, Martin; Lane, Thomas R; Sabbah, Mohamad; Deboosere, Nathalie; Frita, Rosangela; Vandeputte, Alexandre; Hoffmann, Eik; Russo, Riccardo; Connell, Nancy; Veilleux, Courtney; Jha, Rajiv K; Kumar, Pradeep; Freundlich, Joel S; Brodin, Priscille; Aínsa, Jose Antonio; Nagaraja, Valakunja; Maxwell, Anthony; Mikusová, Katarína; Pasca, Maria Rosalia; Ekins, Sean.
Afiliación
  • Mori G; Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.
  • Orena BS; Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.
  • Franch C; Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.
  • Mitchenall LA; Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.
  • Godbole AA; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.
  • Rodrigues L; Departamento de Microbiología, Facultad de Medicina, and BIFI, Universidad de Zaragoza, and IIS-Aragón, 50009 Zaragoza, Spain; CIBER Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Spain; Fundación ARAID, Zaragoza, Spain.
  • Aguilar-Pérez C; Departamento de Microbiología, Facultad de Medicina, and BIFI, Universidad de Zaragoza, and IIS-Aragón, 50009 Zaragoza, Spain; CIBER Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Spain.
  • Zemanová J; Department of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, Ilkovicova 6, 84215, Bratislava, Slovakia.
  • Huszár S; Department of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, Ilkovicova 6, 84215, Bratislava, Slovakia.
  • Forbak M; Department of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, Ilkovicova 6, 84215, Bratislava, Slovakia.
  • Lane TR; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, NC 27606, USA.
  • Sabbah M; Department of Chemistry, University of Cambridge, Lensfield Rd, Cambridge, CB2 1EW, UK.
  • Deboosere N; Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Center for Infection and Immunity of Lille, 1 rue du Professeur Calmette, 59000 Lille, France.
  • Frita R; Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Center for Infection and Immunity of Lille, 1 rue du Professeur Calmette, 59000 Lille, France.
  • Vandeputte A; Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Center for Infection and Immunity of Lille, 1 rue du Professeur Calmette, 59000 Lille, France.
  • Hoffmann E; Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Center for Infection and Immunity of Lille, 1 rue du Professeur Calmette, 59000 Lille, France.
  • Russo R; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
  • Connell N; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
  • Veilleux C; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
  • Jha RK; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.
  • Kumar P; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
  • Freundlich JS; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University - New Jersey
  • Brodin P; Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Center for Infection and Immunity of Lille, 1 rue du Professeur Calmette, 59000 Lille, France.
  • Aínsa JA; Departamento de Microbiología, Facultad de Medicina, and BIFI, Universidad de Zaragoza, and IIS-Aragón, 50009 Zaragoza, Spain; CIBER Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Spain.
  • Nagaraja V; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India; Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India.
  • Maxwell A; Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.
  • Mikusová K; Department of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, Ilkovicova 6, 84215, Bratislava, Slovakia.
  • Pasca MR; Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.
  • Ekins S; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, NC 27606, USA; Collaborative Drug Discovery, 1633 Bayshore Highway, Suite 342, Burlingame, CA 94403, USA. Electronic address: sean@collaborationspharma.com.
Tuberculosis (Edinb) ; 112: 98-109, 2018 09.
Article en En | MEDLINE | ID: mdl-30205975
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rifampin / Proteínas Bacterianas / ARN Polimerasas Dirigidas por ADN / Antibióticos Antituberculosos / Mycobacterium tuberculosis / Naftiridinas / Antimaláricos / Antituberculosos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Tuberculosis (Edinb) Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rifampin / Proteínas Bacterianas / ARN Polimerasas Dirigidas por ADN / Antibióticos Antituberculosos / Mycobacterium tuberculosis / Naftiridinas / Antimaláricos / Antituberculosos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Tuberculosis (Edinb) Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido