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Untargeted search and identification of metabolites of antiviral agent camphecene in rat urine by liquid chromatography and mass spectrometry and studying their distribution in organs following peroral administration of the compound.
Rogachev, Artem D; Yarovaya, Olga I; Fatianova, Alina V; Lavrinenko, Valentina A; Amosov, Evgeny V; Zarubaev, Vladimir V; Pokrovsky, Andrey G; Salakhutdinov, Nariman F.
Afiliación
  • Rogachev AD; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentiev Ave., 9, Novosibirsk, 630090, Russia; Novosibirsk State University, Pirogov Str., 2, Novosibirsk, 630090, Russia. Electronic address: rogachev@nioch.nsc.ru.
  • Yarovaya OI; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentiev Ave., 9, Novosibirsk, 630090, Russia; Novosibirsk State University, Pirogov Str., 2, Novosibirsk, 630090, Russia.
  • Fatianova AV; Novosibirsk State University, Pirogov Str., 2, Novosibirsk, 630090, Russia.
  • Lavrinenko VA; Novosibirsk State University, Pirogov Str., 2, Novosibirsk, 630090, Russia.
  • Amosov EV; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentiev Ave., 9, Novosibirsk, 630090, Russia.
  • Zarubaev VV; Pasteur Institute of Epidemiology and Microbiology, 14 Mira St., 197101, St. Petersburg, Russia.
  • Pokrovsky AG; Novosibirsk State University, Pirogov Str., 2, Novosibirsk, 630090, Russia.
  • Salakhutdinov NF; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentiev Ave., 9, Novosibirsk, 630090, Russia; Novosibirsk State University, Pirogov Str., 2, Novosibirsk, 630090, Russia.
J Pharm Biomed Anal ; 161: 383-392, 2018 Nov 30.
Article en En | MEDLINE | ID: mdl-30205302
Major metabolites of camphecene, a new effective antiviral agent, formed after its oral administration to rats and excreted in the urine, were found and identified using liquid chromatography coupled to mass spectrometry as well as multivariate analysis of HPLC-MS data. The metabolites were found to be camphecene glucuronide, camphecene sulfate and the corresponding iminoacid. A study of the dynamics of accumulation of camphecene and its metabolites in the liver, kidneys, lungs and brain of animals was performed. Maximum concentration of camphecene in blood and organs was reached after 1.5-2 h of its administration, and the maximal content of the agent in the organs investigated was observed in the kidneys. The content of the substance in the lungs was comparable to that in the liver. Also, camphecene was found in brain in high concentration, thus allowing assumption of its ability to penetrate the blood-brain barrier and to exert its antiviral properties in the organ. Camphecene glucuronide and iminoacid had concentration-time profiles similar to that of their precursor, their content being maximal in kidney and liver and 2-3 orders of magnitude higher than in lungs and brain. The content of camphecene sulfate was of similar level in all organs studied. The results obtained made it possible to develop recommendations for therapy with the use of camphecene.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Alcanfor / Etanolaminas Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies Límite: Animals Idioma: En Revista: J Pharm Biomed Anal Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Alcanfor / Etanolaminas Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies Límite: Animals Idioma: En Revista: J Pharm Biomed Anal Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido