Your browser doesn't support javascript.
loading
Cross-talk between lung cancer and bones results in neutrophils that promote tumor progression.
Azevedo, Patrick O; Paiva, Ana E; Santos, Gabryella S P; Lousado, Luiza; Andreotti, Julia P; Sena, Isadora F G; Tagliati, Carlos A; Mintz, Akiva; Birbrair, Alexander.
Afiliación
  • Azevedo PO; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Paiva AE; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Santos GSP; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Lousado L; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Andreotti JP; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Sena IFG; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Tagliati CA; Department of Clinical and Toxicological Analysis, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Mintz A; Department of Radiology, Columbia University Medical Center, New York, NY, USA.
  • Birbrair A; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. birbrair@icb.ufmg.br.
Cancer Metastasis Rev ; 37(4): 779-790, 2018 12.
Article en En | MEDLINE | ID: mdl-30203108
Lung cancer is the leading cause of cancer mortality around the world. The lack of detailed understanding of the cellular and molecular mechanisms participating in the lung tumor progression restrains the development of efficient treatments. Recently, by using state-of-the-art technologies, including in vivo sophisticated Cre/loxP technologies in combination with lung tumor models, it was revealed that osteoblasts activate neutrophils that promote tumor growth in the lung. Strikingly, genetic ablation of osteoblasts abolished lung tumor progression via interruption of SiglecFhigh-expressing neutrophils supply to the tumor microenvironment. Interestingly, SiglecFhigh neutrophil signature was associated with worse lung adenocarcinoma patients outcome. This study identifies novel cellular targets for lung cancer treatment. Here, we summarize and evaluate recent advances in our understanding of lung tumor microenvironment.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoblastos / Comunicación Celular / Neoplasias Pulmonares / Neutrófilos Límite: Animals / Humans Idioma: En Revista: Cancer Metastasis Rev Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoblastos / Comunicación Celular / Neoplasias Pulmonares / Neutrófilos Límite: Animals / Humans Idioma: En Revista: Cancer Metastasis Rev Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos