Cobalt-catalyzed nucleophilic addition of the allylic C(sp<sup>3</sup>)-H bond of simple alkenes to ketones.

Mita, Tsuyoshi; Uchiyama, Masashi; Michigami, Kenichi; Sato, Yoshihiro

Cobalt-catalyzed nucleophilic addition of the allylic C(sp³)-H bond of simple alkenes to ketones.

Mita, Tsuyoshi; Uchiyama, Masashi; Michigami, Kenichi; Sato, Yoshihiro.

Afiliación

Mita T; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Uchiyama M; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Michigami K; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Sato Y; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

Beilstein J Org Chem ; 14: 2012-2017, 2018.

Article en En | MEDLINE | ID: mdl-30202455

RESUMEN

We herein describe a cobalt/Xantphos-catalyzed regioselective addition of simple alkenes to acetophenone derivatives, affording branched homoallylic alcohols in high yields with perfect branch selectivities. The intermediate of the reaction would be a nucleophilic allylcobalt(I) species generated via cleavage of the low reactive allylic C(sp3)-H bond of simple terminal alkenes.

Palabras clave

C(sp3)H bonds; CH activation; alkenes; cobalt; ketones

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Beilstein J Org Chem Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania

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