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An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells.
Aschenbrenner, Dominik; Foglierini, Mathilde; Jarrossay, David; Hu, Dan; Weiner, Howard L; Kuchroo, Vijay K; Lanzavecchia, Antonio; Notarbartolo, Samuele; Sallusto, Federica.
Afiliación
  • Aschenbrenner D; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland.
  • Foglierini M; Translational Gastroenterology Unit, NDM Experimental Medicine, University of Oxford, Oxford, UK.
  • Jarrossay D; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland.
  • Hu D; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
  • Weiner HL; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland.
  • Kuchroo VK; Ann Romney Center for Neurologic Diseases and Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Lanzavecchia A; Ann Romney Center for Neurologic Diseases and Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Notarbartolo S; Ann Romney Center for Neurologic Diseases and Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Sallusto F; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland.
Nat Immunol ; 19(10): 1126-1136, 2018 10.
Article en En | MEDLINE | ID: mdl-30201991
Different types of effector and memory T lymphocytes are induced and maintained in protective or pathological immune responses. Here we characterized two human CD4+ TH17 helper cell subsets that, in the recently activated state, could be distinguished on the basis of their expression of the anti-inflammatory cytokine IL-10. IL-10+ TH17 cells upregulated a variety of genes encoding immunoregulatory molecules, as well as genes whose expression is characteristic of tissue-resident T cells. In contrast, IL-10- TH17 cells maintained a pro-inflammatory gene-expression profile and upregulated the expression of homing receptors that guide recirculation from tissues to blood. Expression of the transcription factor c-MAF was selectively upregulated in IL-10+ TH17 cells, and it was bound to a large set of enhancer-like regions and modulated the immunoregulatory and tissue-residency program. Our results identify c-MAF as a relevant factor that drives two highly divergent post-activation fates of human TH17 cells and provide a framework with which to investigate the role of these cells in physiology and immunopathology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Subgrupos de Linfocitos T / Interleucina-10 / Proteínas Proto-Oncogénicas c-maf / Células Th17 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Subgrupos de Linfocitos T / Interleucina-10 / Proteínas Proto-Oncogénicas c-maf / Células Th17 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos