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Brain neurokinin-1 receptor availability in never-medicated patients with major depression - A pilot study.
Nyman, Mikko; Eskola, Olli; Kajander, Jaana; Jokinen, Riitta; Penttinen, Jukka; Karjalainen, Tomi; Nummenmaa, Lauri; Hirvonen, Jussi; Burns, Donald; Hargreaves, Richard; Solin, Olof; Hietala, Jarmo.
Afiliación
  • Nyman M; Turku PET Centre, Neuropsychiatric Imaging, Turku, Finland; Department of Radiology, University of Turku and Turku University Hospital, Turku, Finland.
  • Eskola O; Turku PET Centre, Radiopharmaceutical Chemistry Laboratory, Turku, Finland.
  • Kajander J; Turku PET Centre, Neuropsychiatric Imaging, Turku, Finland.
  • Jokinen R; Department of Psychiatry, University of Turku and Turku University Hospital, Turku, Finland.
  • Penttinen J; Department of Psychiatry, University of Turku and Turku University Hospital, Turku, Finland.
  • Karjalainen T; Turku PET Centre, Neuropsychiatric Imaging, Turku, Finland.
  • Nummenmaa L; Turku PET Centre, Neuropsychiatric Imaging, Turku, Finland.
  • Hirvonen J; Turku PET Centre, Neuropsychiatric Imaging, Turku, Finland; Department of Radiology, University of Turku and Turku University Hospital, Turku, Finland.
  • Burns D; Imaging Research, Merck Research Laboratories, West Point, PA, USA.
  • Hargreaves R; Imaging Research, Merck Research Laboratories, West Point, PA, USA.
  • Solin O; Turku PET Centre, Radiopharmaceutical Chemistry Laboratory, Turku, Finland; Department of Chemistry, University of Turku, Turku, Finland.
  • Hietala J; Turku PET Centre, Neuropsychiatric Imaging, Turku, Finland; Department of Psychiatry, University of Turku and Turku University Hospital, Turku, Finland. Electronic address: jahi@utu.fi.
J Affect Disord ; 242: 188-194, 2019 01 01.
Article en En | MEDLINE | ID: mdl-30193189
BACKGROUND: Neurotransmitter substance P (SP) and its preferred neurokinin-1 receptor (NK1R) have been implicated in the treatment of affective and addiction disorders. Despite promising preclinical data on antidepressant action, the clinical trials of NK1R antagonists in major depression have been disappointing. There are no direct in vivo imaging studies on NK1R characteristics in patients with a major depressive disorder (MDD). METHODS: In this cross-sectional case-control study, we recruited nine never-medicated patients with moderate to severe MDD and nine matched healthy controls. NK1R availability (NK1R binding potential, BPND) was measured with in vivo 3-D positron emission tomography and a specific NK1 receptor tracer [18F]SPA-RQ. Clinical symptoms were assessed with the 17-item Hamilton Rating Scale for Depression (HAM-D17). RESULTS: NK1R-BPND did not differ statistically significantly between patients with MDD and healthy controls. HAM-D17 total scores (range 21-32) correlated positively with NK1R-BPND in cortical and limbic areas. HAM-D17 subscale score for anxiety symptoms correlated positively with NK1R-BPND in specific brain areas implicated in fear and anxiety. LIMITATIONS: Small sample size. Low variability in the clinical HAM-D subscale ratings may affect the observed correlations. CONCLUSIONS: Our preliminary results do not support a different baseline expression of NK1Rs in a representative sample of never-medicated patients with MDD during a current moderate/severe depressive episode. The modulatory effect of NK1Rs on affective symptoms is in line with early positive results on antidepressant action of NK1 antagonists. However, the effect is likely to be too weak for treatment of MDD with NK1R antagonists alone in clinical practice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Química Encefálica / Receptores de Neuroquinina-1 / Trastorno Depresivo Mayor Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Affect Disord Año: 2019 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Química Encefálica / Receptores de Neuroquinina-1 / Trastorno Depresivo Mayor Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Affect Disord Año: 2019 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Países Bajos