[NOTHROMBEL EFFECT ON THE EXPRESSION OF MEMBRANE COMPLEX GPIb-IX-V PLATELETS ACTIVATED BY THROMBIN].

Veselkina, O S; Petrishchev, N N; Vasina, L V; Borovitov, M E; Seljutin, A V; Chepanov, S V; Sel'kov, S A

Veselkina, O S; Petrishchev, N N; Vasina, L V; Borovitov, M E; Seljutin, A V; Chepanov, S V; Sel'kov, S A.

Ross Fiziol Zh Im I M Sechenova ; 102(5): 590-6, 2016 May.

Article en Ru | MEDLINE | ID: mdl-30192476

RESUMEN

The influence of Nothrombel on the expression of membrane complex GPIb-IX-V of platelets activated by thrombin was studied. It is established that Nothrombel reduced thrombin-induced expression of complex GPIb-IX-V on the membrane of the activated platelets. The inhibitory activity of Nothrombel on the expression of GPIb (CD42b) was comparable to its activity with respect to GPIX (CD42a) and is equal to 43 %. With regard to GPV (CD42d) inhibitory effect of the drug was less pronounced and is equal to 22 %. The possible targets for Nothrombel are activation of thromboxane signaling pathway, as well as GPIb-IX-V receptors of platelets itself.

Asunto(s)

Plaquetas/efectos de los fármacos; Fármacos Hematológicos/farmacología; Piperazinas/farmacología; Complejo GPIb-IX de Glicoproteína Plaquetaria/genética; Adulto; Plaquetas/metabolismo; Células Cultivadas; Femenino; Fármacos Hematológicos/química; Humanos; Masculino; Piperazinas/química; Trombina/farmacología; Tromboxanos/metabolismo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperazinas / Plaquetas / Complejo GPIb-IX de Glicoproteína Plaquetaria / Fármacos Hematológicos Límite: Adult / Female / Humans / Male Idioma: Ru Revista: Ross Fiziol Zh Im I M Sechenova Asunto de la revista: FISIOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Rusia

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