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JMJD6 regulates histone H2A.X phosphorylation and promotes autophagy in triple-negative breast cancer cells via a novel tyrosine kinase activity.
Liu, Yan; Long, Yue-Hong; Wang, Shu-Qing; Zhang, Yuan-Yue; Li, Yu-Feng; Mi, Jiang-Sheng; Yu, Cheng-Hua; Li, De-Yan; Zhang, Jing-Hua; Zhang, Xiao-Jun.
Afiliación
  • Liu Y; College of Life Science, North China University of Science and Technology, Tangshan, China.
  • Long YH; Cancer Institute, Tangshan People's Hospital, Tangshan, China.
  • Wang SQ; College of Life Science, North China University of Science and Technology, Tangshan, China.
  • Zhang YY; Hospital of North China University of Science and Technology, Tangshan, China. 044a141211@ncst.edu.cn.
  • Li YF; College of Life Science, North China University of Science and Technology, Tangshan, China.
  • Mi JS; Cancer Institute, Tangshan People's Hospital, Tangshan, China.
  • Yu CH; Cancer Institute, Tangshan People's Hospital, Tangshan, China.
  • Li DY; People's Hospital of Zunhua, Zunhua, China.
  • Zhang JH; People's Hospital of Zunhua, Zunhua, China.
  • Zhang XJ; People's Hospital of Zunhua, Zunhua, China.
Oncogene ; 38(7): 980-997, 2019 02.
Article en En | MEDLINE | ID: mdl-30185813
Overexpression of Jumonji domain-containing 6 (JMJD6) has been reported to be associated with more aggressive breast cancer characteristics. However, the precise role of JMJD6 in breast cancer development remains unclear. Here, we demonstrate that JMJD6 has intrinsic tyrosine kinase activity and can utilize ATP and GTP as phosphate donors to phosphorylate Y39 of histone H2A.X (H2A.XY39ph). High JMJD6 levels promoted autophagy in triple negative breast cancer (TNBC) cells by regulating the expression of autophagy-related genes. The JMJD6-H2A.XY39ph axis promoted TNBC cell growth via the autophagy pathway. We show that combined inhibition of JMJD6 kinase activity and autophagy efficiently decreases TNBC growth. Together, these findings suggest an effective strategy for TNBC treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autofagia / Histonas / Histona Demetilasas con Dominio de Jumonji / Neoplasias de la Mama Triple Negativas / Proteínas de Neoplasias Límite: Animals / Female / Humans Idioma: En Revista: Oncogene Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autofagia / Histonas / Histona Demetilasas con Dominio de Jumonji / Neoplasias de la Mama Triple Negativas / Proteínas de Neoplasias Límite: Animals / Female / Humans Idioma: En Revista: Oncogene Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido