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A Context-Based Analgesia Model in Rats: Involvement of Prefrontal Cortex.
Xu, Lingchi; Wan, Yalan; Ma, Longyu; Zheng, Jie; Han, Bingxuan; Liu, Feng-Yu; Yi, Ming; Wan, You.
Afiliación
  • Xu L; Neuroscience Research Institute, Peking University, Beijing, 100083, China.
  • Wan Y; Department of Clinical Medicine, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China.
  • Ma L; Neuroscience Research Institute, Peking University, Beijing, 100083, China.
  • Zheng J; Neuroscience Research Institute, Peking University, Beijing, 100083, China.
  • Han B; Neuroscience Research Institute, Peking University, Beijing, 100083, China.
  • Liu FY; Neuroscience Research Institute, Peking University, Beijing, 100083, China.
  • Yi M; Neuroscience Research Institute, Peking University, Beijing, 100083, China.
  • Wan Y; Neuroscience Research Institute, Peking University, Beijing, 100083, China. ywan@hsc.pku.edu.cn.
Neurosci Bull ; 34(6): 1047-1057, 2018 Dec.
Article en En | MEDLINE | ID: mdl-30178433
Cognition and pain share common neural substrates and interact reciprocally: chronic pain compromises cognitive performance, whereas cognitive processes modulate pain perception. In the present study, we established a non-drug-dependent rat model of context-based analgesia, where two different contexts (dark and bright) were matched with a high (52°C) or low (48°C) temperature in the hot-plate test during training. Before and after training, we set the temperature to the high level in both contexts. Rats showed longer paw licking latencies in trials with the context originally matched to a low temperature than those to a high temperature, indicating successful establishment of a context-based analgesic effect in rats. This effect was blocked by intraperitoneal injection of naloxone (an opioid receptor antagonist) before the probe. The context-based analgesic effect also disappeared after optogenetic activation or inhibition of the bilateral infralimbic or prelimbic sub-region of the prefrontal cortex. In brief, we established a context-based, non-drug dependent, placebo-like analgesia model in the rat. This model provides a new and useful tool for investigating the cognitive modulation of pain.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Corteza Prefrontal / Umbral del Dolor / Analgésicos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neurosci Bull Asunto de la revista: NEUROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Singapur
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Corteza Prefrontal / Umbral del Dolor / Analgésicos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neurosci Bull Asunto de la revista: NEUROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Singapur