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Nationwide Study on the Course of Influenza A (H1N1) Infections in Hospitalized Children in the Netherlands During the Pandemic 2009-2010.
Ahout, Inge M L; Philipsen, Ria L A; Las, Mariëtte; Baysan, Meryem; Brus, Frank; Rahamat-Langendoen, Jeanette C; Roeleveld, Nel; Fraaij, Pieter L; Osterhaus, Albert D M E; Ferwerda, Gerben; de Groot, Ronald.
Afiliación
  • Ahout IML; From the Department of Pediatrics, Laboratory of Pediatric Infectious Diseases, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Philipsen RLA; From the Department of Pediatrics, Laboratory of Pediatric Infectious Diseases, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Las M; From the Department of Pediatrics, Laboratory of Pediatric Infectious Diseases, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Baysan M; Paediatric Drug Research Centre Nijmegen, Radboudumc Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Brus F; From the Department of Pediatrics, Laboratory of Pediatric Infectious Diseases, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Rahamat-Langendoen JC; Juliana Childrens Hospital, Haga Teaching Hospital, The Hague, The Netherlands.
  • Roeleveld N; Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Fraaij PL; From the Department of Pediatrics, Laboratory of Pediatric Infectious Diseases, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Osterhaus ADME; Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Ferwerda G; Department of Pediatrics, Sophia Childrens Hospital, Erasmus MC, Rotterdam, The Netherlands.
  • de Groot R; Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Pediatr Infect Dis J ; 37(12): e283-e291, 2018 12.
Article en En | MEDLINE | ID: mdl-30169483
BACKGROUND: The influenza H1N1 pandemic of 2009-2010, provided a unique opportunity to assess the course of disease, as well as the analysis of risk factors for severe disease in hospitalized children (< 18 years). METHODS: Retrospective national chart study on hospitalized children with H1N1 infection during the 2009-2010 pH1N1 outbreak. RESULTS: Nine hundred forty patients (56% boys), median age 3.0 years, were enrolled; the majority were previously healthy. Treatment consisted of supplemental oxygen (24%), mechanical ventilation (5%) and antiviral therapy (63%). Fifteen patients died (1.6%), 5 of whom were previously healthy. Multivariable analyses confirmed pre-existent heart and lung disease as risk factors for intensive care unit admission. Risk factors for mortality included children with a neurologic or oncologic disease and psychomotor retardation. CONCLUSIONS: This nationwide overview of hospitalized children confirms known risk groups for severe influenza infections. However, most of the acute and severe presentations of influenza occurred in previously healthy children.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Niño Hospitalizado / Gripe Humana / Subtipo H1N1 del Virus de la Influenza A Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Europa Idioma: En Revista: Pediatr Infect Dis J Asunto de la revista: DOENCAS TRANSMISSIVEIS / PEDIATRIA Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Niño Hospitalizado / Gripe Humana / Subtipo H1N1 del Virus de la Influenza A Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Europa Idioma: En Revista: Pediatr Infect Dis J Asunto de la revista: DOENCAS TRANSMISSIVEIS / PEDIATRIA Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos