Your browser doesn't support javascript.
loading
Joint effect of smoking and NQO1 C609T polymorphism on undifferentiated nasopharyngeal carcinoma risk in a North African population.
Moumad, Khalid; Khaali, Wafa; Benider, Abdellatif; Ben Ayoub, Wided; Hamdi-Cherif, Mokhtar; Boualga, Kada; Hassen, Elham; Ben Driss, El Khalil; Corbex, Marilys; Khyatti, Meriem.
Afiliación
  • Moumad K; Oncovirology Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.
  • Khaali W; Oncovirology Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.
  • Benider A; Departement of Biology, Faculty of Sciences, Abdelmalek Essaadi University, Tetouan, Morocco.
  • Ben Ayoub W; Service de Radiothérapie, Centre d'oncologie Ibn Rochd, Casablanca, Morocco.
  • Hamdi-Cherif M; Association Tunisienne de Lutte Contre le Cancer, Tunis, Tunisia.
  • Boualga K; Service d'épidémiologie, CHU de Sétif, Sétif, Algeria.
  • Hassen E; Service de Radiothérapie Oncologique, Centre Antic-Cancer de Blida, Blida, Algeria.
  • Ben Driss EK; Molecular Immuno-Oncology Laboratory, Faculty of Medicine, Monastir University, Monastir, Tunisia.
  • Corbex M; Departement of Biology, Faculty of Sciences, Abdelmalek Essaadi University, Tetouan, Morocco.
  • Khyatti M; Who Regional Office for Europe, Copenhagen, Denmark.
Mol Genet Genomic Med ; 6(6): 933-940, 2018 11.
Article en En | MEDLINE | ID: mdl-30160047
BACKGROUND: Nasopharyngeal carcinoma (NPC) has a higher incidence in North Africa than in most parts of the world. In addition to environmental factors such as Epstein-Barr virus infection and chemical carcinogen exposure, genetic susceptibility has been reported to play a key role in the development of NPC. NAD(P)H: quinone oxidoreductase 1 is a cytosolic enzyme that protects cells from oxidative damage. A C to T transition at position 609 in the NQO1 gene (OMIM: 125860) has been shown to alter the enzymatic activity of the enzyme and has been associated with increased risk to several cancers. This study investigates for the first time the effect of this polymorphism on NPC susceptibility in a North African population. METHODS: The NQO1 C609T polymorphism was genotyped using PCR-RFLP in 392 NPC cases and 365 controls from Morocco, Algeria, and Tunisia. RESULTS: The allele frequencies and distributions of genotypes did not differ between cases and controls (p > 0.05). When stratifying according to smoking status, we observed two-fold higher NPC risk in ever-smokers carrying the CT or TT genotype. Multiple logistic regression analysis revealed that there was a significant interaction between T allele and smoking status (OR = 1.95, 95% CI = 1.20-3.19; interaction p = 0.007). CONCLUSION: In this North African population, the functional NQO1 polymorphism was associated with a significantly higher risk of NPC among smokers and did not affect the risk among nonsmokers.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fumar / Neoplasias Nasofaríngeas / NAD(P)H Deshidrogenasa (Quinona) / Polimorfismo de Nucleótido Simple / Carcinoma Nasofaríngeo Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Africa Idioma: En Revista: Mol Genet Genomic Med Año: 2018 Tipo del documento: Article País de afiliación: Marruecos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fumar / Neoplasias Nasofaríngeas / NAD(P)H Deshidrogenasa (Quinona) / Polimorfismo de Nucleótido Simple / Carcinoma Nasofaríngeo Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Africa Idioma: En Revista: Mol Genet Genomic Med Año: 2018 Tipo del documento: Article País de afiliación: Marruecos Pais de publicación: Estados Unidos