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Effects of Citrate Acid Concentrate on Hemodialysis Adequacy, Reuse, and Quality of Life: A Prospective Randomized Crossover Trial.
Nagaraju, S P; Kosuru, S; Parthasarathy, R; Mareddy, A S; Attur, R P; Rangaswamy, D; Prasad, S; Kaza, S; Shenoy, S; Saraf, K; Laxminarayana, S L K; Mateti, U V; Guddattu, V.
Afiliación
  • Nagaraju SP; Department of Nephrology, Kasturba Medical College, Manipal University, Udupi, Karnataka, India.
  • Kosuru S; Department of Nephrology, Mahatma Gandhi Hospitals, Narasaraopet, Andhra Pradesh, India.
  • Parthasarathy R; Department of Nephrology, Madras Mission Hospital, Chennai, Tamil Nadu, India.
  • Mareddy AS; Department of Nephrology, Guntur City Hospitals, Guntur, Andhra Pradesh, India.
  • Attur RP; Department of Nephrology, Kasturba Medical College, Manipal University, Udupi, Karnataka, India.
  • Rangaswamy D; Department of Nephrology, Kasturba Medical College, Manipal University, Udupi, Karnataka, India.
  • Prasad S; Department of Nephrology, Kasturba Medical College, Manipal University, Udupi, Karnataka, India.
  • Kaza S; Department of Nephrology, Kasturba Medical College, Manipal University, Udupi, Karnataka, India.
  • Shenoy S; Department of Nephrology, Kasturba Medical College, Manipal University, Udupi, Karnataka, India.
  • Saraf K; Department of Nephrology, Kasturba Medical College, Manipal University, Udupi, Karnataka, India.
  • Laxminarayana SLK; Department of Pathology, Kasturba Medical College, Manipal University, Udupi, Karnataka, India.
  • Mateti UV; Department of Pharmacy Practice, NGSM Institute of Pharmaceutical Sciences, Nitte University, Mangalore, Karnataka, India.
  • Guddattu V; Department of Statistics, Prasanna School of Public Health, Manipal University, Manipal, Karnataka, India.
Indian J Nephrol ; 28(4): 287-290, 2018.
Article en En | MEDLINE | ID: mdl-30158747
We conducted a randomized crossover trial to identify whether the use of citrate dialysate (CD) for bicarbonate hemodialysis is beneficial compared to regular acetate dialysate (AD) in terms of adequacy, reuse, and quality of life. Thirty-two stable end-stage renal disease patients on twice-weekly maintenance hemodialysis were randomly assigned to CD or AD fluid in a single-blinded randomized prospective crossover trial of 1-year duration. The primary outcomes studied were the impact of CD in comparison with AD on hemodialysis adequacy, reuse of dialyzer, and quality of life. Secondary outcomes studied were the effect on intradialytic hypotension, acidosis correction, and episodes of symptomatic hypocalcemia. A total number of 28 patients underwent a total of 1456 sessions of hemodialysis with CD over 6 months and 1456 sessions with AD over 6 months. There was a significant increase in dialyzer reuse with the use of CD (P = 0.02). There was no difference in dialyzer adequacy as measured by Single pool Kt/V (spKt/V) (P = 0.840) and urea reduction ratio (%) (P = 0.90). Quality of life did not differ between the two groups. No statistically significant difference was observed in predialysis arterial pH (P = 0.23) serum bicarbonate (0.17) and calcium change (P = 0.16). CD is safe and equally effective as compared to AD. It significantly improves the reuse of dialyzer but it does not offer any added advantage in terms of improvement in hemodialysis adequacy and quality of care.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Aspecto: Patient_preference Idioma: En Revista: Indian J Nephrol Año: 2018 Tipo del documento: Article País de afiliación: India Pais de publicación: India
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Aspecto: Patient_preference Idioma: En Revista: Indian J Nephrol Año: 2018 Tipo del documento: Article País de afiliación: India Pais de publicación: India