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Postmortem tissue distribution of morphine and its metabolites in a series of heroin-related deaths.
Maskell, Peter D; Wilson, Nathan E; Seetohul, L Nitin; Crichton, Megan L; Beer, Lewis J; Drummond, Gail; De Paoli, Giorgia.
Afiliación
  • Maskell PD; School of Science, Engineering and Technology, Abertay University, Dundee, DD11HG, UK.
  • Wilson NE; University of Dundee, Dundee, DD1 4HN, UK.
  • Seetohul LN; School of Science and Technology, Nottingham Trent University, Nottingham, UK.
  • Crichton ML; University of Dundee, Dundee, DD1 4HN, UK.
  • Beer LJ; University of Dundee, Dundee, DD1 4HN, UK.
  • Drummond G; University of Dundee, Dundee, DD1 4HN, UK.
  • De Paoli G; NHS Tayside, Ninewells Hospital, Dundee, UK.
Drug Test Anal ; 11(2): 292-304, 2019 Feb.
Article en En | MEDLINE | ID: mdl-30156385
The abuse of heroin (diamorphine) and heroin-related deaths are increasing around the world. The interpretation of the toxicological results from suspected heroin-related deaths is notoriously difficult, especially in cases where there may be limited samples. To help forensic practitioners with heroin interpretation, we determined the concentration of morphine (M), morphine-3-glucuronide (M3G), and morphine-6-glucuronide (M6G) in blood (femoral and cardiac), brain (thalamus), liver (deep right lobe), bone marrow (sternum), skeletal muscle (psoas), and vitreous humor in 44 heroin-related deaths. The presence of 6-monoacetylmorphine (6-MAM) in any of the postmortem samples was used as confirmation of heroin use. Quantitation was carried out using a validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) method with solid-phase extraction. We also determined the presence of papaverine, noscapine and codeine in the samples, substances often found in illicit heroin and that may help determine illicit heroin use. The results of this study show that vitreous is the best sample to detect 6-MAM (100% of cases), and thus heroin use. The results of the M, M3G, and M6G quantitation in this study allow a degree of interpretation when samples are limited. However in some cases it may not be possible to determine heroin/morphine use as in four cases in muscle (three cases in bone marrow) no morphine, M3G, or M6G were detected, even though they were detected in other case samples. As always, postmortem cases of suspected morphine/heroin intoxication should be interpreted with care and with as much case knowledge as possible.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Heroína / Morfina / Derivados de la Morfina Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Drug Test Anal Asunto de la revista: FARMACOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Heroína / Morfina / Derivados de la Morfina Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Drug Test Anal Asunto de la revista: FARMACOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido