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TP53 gene Arg72Pro polymorphism and male infertility risk: A meta-analysis.
Ren, Zheng-Ju; Zhang, Qin; Ren, Peng-Wei; Yang, Bo; Liu, Sheng-Zhuo; Liao, Jian; Yang, Lu-Cheng; Lu, Dong-Liang; Liu, Liang-Ren; Dong, Qiang.
Afiliación
  • Ren ZJ; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
  • Zhang Q; Department of Radiology, Chongqing Traditional Chinese Medicine Hospital, Chongqing, China.
  • Ren PW; Department of Evidence-Based Medicine and Clinical Epidemiology, West China Hospital, Sichuan University, Chengdu, China.
  • Yang B; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
  • Liu SZ; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
  • Liao J; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
  • Yang LC; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
  • Lu DL; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
  • Liu LR; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
  • Dong Q; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Andrologia ; 50(10): e13122, 2018 Dec.
Article en En | MEDLINE | ID: mdl-30155914
To evaluate the association between TP53 codon72 polymorphism and male infertility risk. We conducted a search on Medline, Embase, Web of Science and CNKI up to April 30, 2017. Odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the strength of the association. Seven studies including 1,818 cases and 2,278 controls met the inclusion criteria. The pooled results indicated that no significant association was observed between TP53 codon72 polymorphism and male infertility risk (G versus C: OR = 1.11, 95%CI = 0.94-1.32; GG versus CC: OR = 1.26, 95%CI = 0.90-1.78; GG versus GC+CC: OR = 1.16, 95%CI = 0.90-1.49; GG+GC versus CC: OR = 1.15, 95%CI = 0.88-1.49). In the subgroup analysis by ethnicity, significant association was observed between TP53 codon72 polymorphism and male infertility risk in non-Chinese (G versus C: OR = 1.47, 95%CI = 1.14-1.89), but not in Chinese population (G versus C: OR = 1.03, 95%CI = 0.87-1.22). In conclusion, this study suggested that TP53 codon72 polymorphism might be associated with an increased susceptibility to male infertility in non-Chinese population, but not in Chinese population. Studies with larger sample sizes and representative population-based cases and well-matched controls are needed to validate our results.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína p53 Supresora de Tumor / Predisposición Genética a la Enfermedad / Infertilidad Masculina Tipo de estudio: Etiology_studies / Risk_factors_studies / Systematic_reviews Límite: Humans / Male Idioma: En Revista: Andrologia Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína p53 Supresora de Tumor / Predisposición Genética a la Enfermedad / Infertilidad Masculina Tipo de estudio: Etiology_studies / Risk_factors_studies / Systematic_reviews Límite: Humans / Male Idioma: En Revista: Andrologia Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania