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Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis.
Zhu, Huifang; Wang, Fei; Ju, Xiaoman; Kong, Lingmei; An, Tao; Zhao, Zhangxun; Liu, Jikai; Li, Yan.
Afiliación
  • Zhu H; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China; University of Chinese Academy of Sciences, Beijing, PR China.
  • Wang F; BioBioPha Co., Ltd., 132# Lanhei Road, Kunming, 650201, Yunnan, PR China.
  • Ju X; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China; University of Chinese Academy of Sciences, Beijing, PR China.
  • Kong L; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China.
  • An T; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China.
  • Zhao Z; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China; University of Chinese Academy of Sciences, Beijing, PR China.
  • Liu J; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, Hubei, PR China. Electronic address: jkliu@mail.kib.ac.cn.
  • Li Y; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China. Electronic address: liyan@mail.kib.ac.cn.
Biochem Biophys Res Commun ; 503(4): 3057-3063, 2018 09 18.
Article en En | MEDLINE | ID: mdl-30144974
The natural killer group 2D (NKG2D) receptor on natural killer (NK) cells play an important role in immunosurveillance to cancer cells, which could mediate the eradication of tumor cells through specific interactions with NKG2D ligands on tumor cells. Here we report one natural compound aurovertin B from basidiomycete Albatrellus confluens significantly stimulates the expression of NKG2D ligands on tumor cells, which greatly sensitizes its recognition and lysis by NK cell. It is completely a novel role for aurovertin B to target tumor cells to death mediated by NK cells and our findings indicate aurovertin B may deserve further development as sensitizing agent in NK cell mediated cancer immunotherapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aurovertinas / Células Asesinas Naturales / Neoplasias Colorrectales / Citotoxicidad Inmunológica / Péptidos y Proteínas de Señalización Intercelular / Antineoplásicos Límite: Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aurovertinas / Células Asesinas Naturales / Neoplasias Colorrectales / Citotoxicidad Inmunológica / Péptidos y Proteínas de Señalización Intercelular / Antineoplásicos Límite: Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos