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Glomerular filtration rate: A prognostic marker in atrial fibrillation-A subanalysis of the AntiThrombotic Agents Atrial Fibrillation.
Proietti, Riccardo; Gonzini, Lucio; Pizzimenti, Giovanni; Ledda, Antonietta; Sanna, Pietro; AlTurki, Ahmed; Russo, Vincenzo; Lencioni, Mauro.
Afiliación
  • Proietti R; Department of Cardiac, Thoracic, and Vascular Sciences, University of Padua, Padua, Italy.
  • Gonzini L; ANMCO Research Center, Florence, Italy.
  • Pizzimenti G; Cardiology Department, Giuseppe Fogliani Hospital, Milazzo, Italy.
  • Ledda A; Cardiology Department, Azienda Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy.
  • Sanna P; Cardiology Department, San Francesco Hospital, Nuoro, Italy.
  • AlTurki A; Division of Cardiology, McGill University Health Centre, Montreal, Quebec, Canada.
  • Russo V; Department of Medicine, McGill University, Montreal, Quebec, Canada.
  • Lencioni M; Chair of Cardiology, University of Campania "Luigi Vanvitelli", Ospedale Monaldi, Naples, Italy.
Clin Cardiol ; 41(12): 1570-1577, 2018 Dec.
Article en En | MEDLINE | ID: mdl-30144119
OBJECTIVE: An increased cardiovascular mortality and morbidity has been widely reported in patients with atrial fibrillation (AF). In this study, a subanalysis of the AntiThrombotic Agents Atrial Fibrillation (ATA-AF) is performed with the aim to evaluate estimated glomerular filtration rate (eGFR) as an independent prognostic marker of cardiovascular mortality and morbidity in patients with AF. METHODS AND RESULTS: The ATA-AF study enrolled 7148 patients with AF, in 360 Italian centers. The eGFR was calculated from data reported in patient notes or hospital database. This post-hoc analysis included 1097 AF patients with eGFR data available and 1-year clinical follow-up. The endpoint was assessed as cardiovascular mortality and/or hospital admission for cardiovascular causes at follow-up. Patients were also divided in two groups according to the eGFR (<60 and ≥60 mL/min/1.73 m2 ). The Kaplan-Meyer curve for the mentioned endpoint showed a higher endpoint incidence in the group of patient with eGFR below 60 mL/min/1.73 m2 (P < 0.001). Using multivariate analysis (Cox regression), a trend toward a higher rate of occurrence of the primary endpoint was observed for eGFR below 60 mL/min/1.73 m2 without reaching the conventional level of statistical significance (hazard ratio [HR] 1.40; 95% confidence interval [CI] 0.99-1.99; P = 0.0572). When eGFR was included in the analysis as continuous variable a significant correlation was observed with the combined endpoint at the Cox regression (HR 0.99, 95% CI 0.98-0.99, P = 0.04). CONCLUSION: The result of this post-hoc analysis indicates that an impaired eGFR is independently associated with worse prognosis among patients with AF.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrilación Atrial / Medición de Riesgo / Insuficiencia Renal / Fibrinolíticos / Tasa de Filtración Glomerular Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Clin Cardiol Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrilación Atrial / Medición de Riesgo / Insuficiencia Renal / Fibrinolíticos / Tasa de Filtración Glomerular Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Clin Cardiol Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos