IRAK1 Limits TLR3/4- and IFNAR-Driven IL-27 Production through a STAT1-Dependent Mechanism.

Bruni, Daniela; Dignam, Adam; Dunne, Susan; Wall-Coughlan, Devlin; McCrudden, Aisling; O'Connell, Karen; Lyons, Caitriona; McGuigan, Christopher; Tubridy, Niall; Butler, Marion P

Bruni, Daniela; Dignam, Adam; Dunne, Susan; Wall-Coughlan, Devlin; McCrudden, Aisling; O'Connell, Karen; Lyons, Caitriona; McGuigan, Christopher; Tubridy, Niall; Butler, Marion P.

Afiliación

Bruni D; Institute of Immunology, Department of Biology, Maynooth University, Maynooth, County Kildare, Ireland.
Dignam A; Institute of Immunology, Department of Biology, Maynooth University, Maynooth, County Kildare, Ireland.
Dunne S; Institute of Immunology, Department of Biology, Maynooth University, Maynooth, County Kildare, Ireland.
Wall-Coughlan D; Institute of Immunology, Department of Biology, Maynooth University, Maynooth, County Kildare, Ireland.
McCrudden A; Institute of Immunology, Department of Biology, Maynooth University, Maynooth, County Kildare, Ireland.
O'Connell K; Department of Neurology, St. Vincent's University Hospital, Dublin 4, Ireland; and.
Lyons C; School of Medicine, University College Dublin, Dublin 4, Ireland.
McGuigan C; Institute of Immunology, Department of Biology, Maynooth University, Maynooth, County Kildare, Ireland.
Tubridy N; Department of Neurology, St. Vincent's University Hospital, Dublin 4, Ireland; and.
Butler MP; School of Medicine, University College Dublin, Dublin 4, Ireland.

J Immunol ; 201(7): 2070-2081, 2018 10 01.

Article en En | MEDLINE | ID: mdl-30143585

Asunto(s)

Quinasas Asociadas a Receptores de Interleucina-1/metabolismo; Interleucina-27/metabolismo; Macrófagos/metabolismo; Microglía/metabolismo; Receptor de Interferón alfa y beta/metabolismo; Animales; Células HEK293; Humanos; Factor 3 de Genes Estimulados por el Interferón/metabolismo; Quinasas Asociadas a Receptores de Interleucina-1/genética; Ratones; Fosforilación; Receptor de Interferón alfa y beta/genética; Factor de Transcripción STAT1/metabolismo; Transducción de Señal; Receptor Toll-Like 3/metabolismo; Receptor Toll-Like 4/metabolismo

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microglía / Quinasas Asociadas a Receptores de Interleucina-1 / Receptor de Interferón alfa y beta / Interleucina-27 / Macrófagos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Immunol Año: 2018 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Estados Unidos

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