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Hyaluronan-binding protein 2 (HABP2) gene variation in women with recurrent miscarriage.
Husseini-Akram, Frida; Haroun, Sally; Altmäe, Signe; Skjöldebrand-Sparre, Lottie; Åkerud, Helena; Poromaa, Inger Sundström; Landgren, Britt-Marie; Stavreus-Evers, Anneli.
Afiliación
  • Husseini-Akram F; Department of Clinical Sciences, Division of Obstetrics and Gynaecology, Danderyds Hospital, Karolinska Institutet, Stockholm, Sweden.
  • Haroun S; Department of Women's and Children's Health, Uppsala University, 751 85, Uppsala, Sweden.
  • Altmäe S; Competence Centre on Health Technologies, Tartu, Estonia.
  • Skjöldebrand-Sparre L; Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Granada, Spain.
  • Åkerud H; Department of Clinical Sciences, Division of Obstetrics and Gynaecology, Danderyds Hospital, Karolinska Institutet, Stockholm, Sweden.
  • Poromaa IS; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Landgren BM; Department of Women's and Children's Health, Uppsala University, 751 85, Uppsala, Sweden.
  • Stavreus-Evers A; Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
BMC Womens Health ; 18(1): 143, 2018 08 24.
Article en En | MEDLINE | ID: mdl-30143058
BACKGROUND: Idiopathic recurrent miscarriage, defined as three or more consecutive miscarriages, is a distressing early pregnancy complication. Although, the etiology of recurrent miscarriage is still unknown, an aberrant regulation of the endometrial receptivity marker hyaluronan-binding protein 2 (HABP2) has been suggested. The objective of the present study was to investigate the effect of genetic variations of HABP2 in women with idiopathic recurrent miscarriage compared to fertile women. METHODS: This study was designed as a case-control study. In total, 165 women who had three or more consecutive miscarriages and 289 fertile women were included in the study. Polymorphisms in the HABP2 gene were analyzed using TaqMan SNP Genotyping Assays. Three polymorphisms in the HABP2 gene, rs1157916, rs2240879 and rs7080536 (Marburg I) were studied. RESULTS: Polymorphism in HABP2 showed no significant difference in women with recurrent miscarriage compared to fertile women, except for rs1157916 minor A allele that was more prevalent among RM patients (p = 0.058). Significantly higher live birth rate was observed among women with three to four miscarriages compared to those with more miscarriages (p = 0.001). CONCLUSIONS: Variations in the HABP2 gene did not seem to be involved in the etiology of recurrent miscarriage, while, the number of previous miscarriages had an impact on the live birth rate.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Serina Endopeptidasas / Aborto Habitual / Receptores de Hialuranos / Nacimiento Vivo Tipo de estudio: Observational_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: BMC Womens Health Asunto de la revista: SAUDE DA MULHER Año: 2018 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Serina Endopeptidasas / Aborto Habitual / Receptores de Hialuranos / Nacimiento Vivo Tipo de estudio: Observational_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: BMC Womens Health Asunto de la revista: SAUDE DA MULHER Año: 2018 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido