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Time course of diffusion tensor imaging metrics in the chronic spinal cord compression rat model.
Zheng, Weipeng; Xu, Fangtian; Chen, Haoyi; Wang, Ning; Xiao, Wende; Liang, YingJie; Wen, Shifeng.
Afiliación
  • Zheng W; 1 Department of Orthopedics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, PR China.
  • Xu F; 2 Department of Orthopedics, The First Affiliated Hospital of Gannan Medical University, Ganzhou, PR China.
  • Chen H; 1 Department of Orthopedics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, PR China.
  • Wang N; 1 Department of Orthopedics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, PR China.
  • Xiao W; 1 Department of Orthopedics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, PR China.
  • Liang Y; 3 Department of Orthopedics, First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, PR China.
  • Wen S; 1 Department of Orthopedics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Acta Radiol ; 60(5): 653-662, 2019 May.
Article en En | MEDLINE | ID: mdl-30142996
BACKGROUND: Diffusion tensor imaging (DTI) provides information about water molecule diffusion in spinal cord. PURPOSE: This study was aimed to investigate DTI changes in the different stages of compressive spinal cord induced by water-absorbing material implantation. MATERIAL AND METHODS: The spinal cord compression was administered over the fourth cervical vertebral level in rat. Rat models were divided into five subgroups according to compression stages: sham group, group A: three-day compression rat models; group B: 12-day compression rat models; group C: 20-day compression rat models; group D: 60-day compression rat models. DTI including fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in the compressive spinal cord were collected. The relationship between the Basso, Beattie, and Bresnahan (BBB) scores and DTI metrics was further explored. RESULTS: Compared with the sham group, BBB scoring of rat model showed a decreased tendency from group A ( P < 0.05) to group B ( P < 0.05). Then the motor function of rat model hindlimbs was recovered in some degree from group C ( P < 0.05) to group D ( P < 0.05) but had significant motor defects when compared with the normal level ( P < 0.05). The DTI metrics results revealed that chronic spinal cord compression resulted in lower FA value and higher ADC value at the compressive spinal cord level assessed at all four time-points ( P < 0.05). DTI metrics also showed a close correlation with motor function ( P < 0.05). CONCLUSION: DTI is an optimal pre-clinical imaging tool to reflect locomotor performance and pathological status of compressive spinal cord epicenter in chronic spinal cord compression rat model.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compresión de la Médula Espinal / Imagen de Difusión Tensora Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Acta Radiol Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compresión de la Médula Espinal / Imagen de Difusión Tensora Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Acta Radiol Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido