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Human leukocyte antigen-G 3' untranslated region polymorphisms are associated with asthma severity.
Alves, Cinthia C; Arruda, Luísa K P; Oliveira, Fabíola R; Massaro, Juliana D; Aquino, Beatriz J; Paz, Michelle A; Castelli, Erick C; Mendes-Junior, Celso T; Donadi, Eduardo A.
Afiliación
  • Alves CC; Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. Electronic address: cinthiacalves@usp.br.
  • Arruda LKP; Department of Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
  • Oliveira FR; Department of Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
  • Massaro JD; Department of Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
  • Aquino BJ; Department of Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
  • Paz MA; São Paulo State University (UNESP), School of Medicine, Molecular Genetics and Bioinformatics Laboratory, Botucatu, SP, Brazil.
  • Castelli EC; São Paulo State University (UNESP), School of Medicine, Molecular Genetics and Bioinformatics Laboratory, Botucatu, SP, Brazil; São Paulo State University (UNESP), School of Medicine, Department of Pathology, Botucatu, SP, Brazil.
  • Mendes-Junior CT; Departamento de Química, Laboratório de Pesquisas Forenses e Genômicas, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
  • Donadi EA; Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil; Department of Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
Mol Immunol ; 101: 500-506, 2018 09.
Article en En | MEDLINE | ID: mdl-30142579
Asthma is a genetically complex chronic inflammatory airway disorder, and according to disease pathogenesis, clinical manifestations may vary according to asthma severity. A gene region close to the human leukocyte antigen-G (HLA-G) gene was identified as an independent susceptibility marker for asthma. Considering that the HLA-G immune checkpoint molecule may modulate inflammation, we evaluated the diversity of the HLA-G 3' untranslated region (3'UTR) in asthmatic patients stratified according to disease severity. We evaluate the entire HLA-G 3'UTR segment in 115 Brazilian patients stratified into mild (n=29), moderate (n=21) and severe asthmatics (n=65), and in 116 healthy individuals. HLA-G 3'UTR typing was performed using Sanger sequencing. The multiple comparisons among patients stratified according to disease severity revealed several associations; however, after Bonferroni's correction, the following results remained significant: i) the +3010C and +3142G alleles were overrepresented in mild asthma patients when compared to controls; ii) the +3010G and +3142C alleles were overrepresented in severe asthma patients in comparison to patients with mild asthma. In conclusion, the +3010C/G and +3142C/G HLA-G 3'UTR variation sites were differentially associated according to asthma severity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Índice de Severidad de la Enfermedad / Predisposición Genética a la Enfermedad / Regiones no Traducidas 3' / Polimorfismo de Nucleótido Simple / Antígenos HLA-G Tipo de estudio: Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Mol Immunol Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Índice de Severidad de la Enfermedad / Predisposición Genética a la Enfermedad / Regiones no Traducidas 3' / Polimorfismo de Nucleótido Simple / Antígenos HLA-G Tipo de estudio: Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Mol Immunol Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido