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Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1.
Schoepfer, Joseph; Jahnke, Wolfgang; Berellini, Giuliano; Buonamici, Silvia; Cotesta, Simona; Cowan-Jacob, Sandra W; Dodd, Stephanie; Drueckes, Peter; Fabbro, Doriano; Gabriel, Tobias; Groell, Jean-Marc; Grotzfeld, Robert M; Hassan, A Quamrul; Henry, Chrystèle; Iyer, Varsha; Jones, Darryl; Lombardo, Franco; Loo, Alice; Manley, Paul W; Pellé, Xavier; Rummel, Gabriele; Salem, Bahaa; Warmuth, Markus; Wylie, Andrew A; Zoller, Thomas; Marzinzik, Andreas L; Furet, Pascal.
Afiliación
  • Schoepfer J; Novartis Institutes for BioMedical Research, Novartis Campus , CH-4056 Basel , Switzerland.
  • Jahnke W; Novartis Institutes for BioMedical Research, Novartis Campus , CH-4056 Basel , Switzerland.
  • Cotesta S; Novartis Institutes for BioMedical Research, Novartis Campus , CH-4056 Basel , Switzerland.
  • Cowan-Jacob SW; Novartis Institutes for BioMedical Research, Novartis Campus , CH-4056 Basel , Switzerland.
  • Dodd S; Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue , Cambridge , Massachusetts 02139 , United States.
  • Drueckes P; Novartis Institutes for BioMedical Research, Novartis Campus , CH-4056 Basel , Switzerland.
  • Gabriel T; Novartis Institutes for BioMedical Research, Novartis Campus , CH-4056 Basel , Switzerland.
  • Groell JM; Novartis Institutes for BioMedical Research, Novartis Campus , CH-4056 Basel , Switzerland.
  • Grotzfeld RM; Novartis Institutes for BioMedical Research, Novartis Campus , CH-4056 Basel , Switzerland.
  • Henry C; Novartis Institutes for BioMedical Research, Novartis Campus , CH-4056 Basel , Switzerland.
  • Jones D; Novartis Institutes for BioMedical Research, Novartis Campus , CH-4056 Basel , Switzerland.
  • Loo A; Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue , Cambridge , Massachusetts 02139 , United States.
  • Manley PW; Novartis Institutes for BioMedical Research, Novartis Campus , CH-4056 Basel , Switzerland.
  • Pellé X; Novartis Institutes for BioMedical Research, Novartis Campus , CH-4056 Basel , Switzerland.
  • Rummel G; Novartis Institutes for BioMedical Research, Novartis Campus , CH-4056 Basel , Switzerland.
  • Salem B; Novartis Institutes for BioMedical Research, Novartis Campus , CH-4056 Basel , Switzerland.
  • Zoller T; Novartis Institutes for BioMedical Research, Novartis Campus , CH-4056 Basel , Switzerland.
  • Marzinzik AL; Novartis Institutes for BioMedical Research, Novartis Campus , CH-4056 Basel , Switzerland.
  • Furet P; Novartis Institutes for BioMedical Research, Novartis Campus , CH-4056 Basel , Switzerland.
J Med Chem ; 61(18): 8120-8135, 2018 09 27.
Article en En | MEDLINE | ID: mdl-30137981
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Leucemia Mielógena Crónica BCR-ABL Positiva / Proteínas de Fusión bcr-abl / Niacinamida / Inhibidores de Proteínas Quinasas / Descubrimiento de Drogas Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Leucemia Mielógena Crónica BCR-ABL Positiva / Proteínas de Fusión bcr-abl / Niacinamida / Inhibidores de Proteínas Quinasas / Descubrimiento de Drogas Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos