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Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques.
O'Connor, Megan A; Tisoncik-Go, Jennifer; Lewis, Thomas B; Miller, Charlene J; Bratt, Debra; Moats, Cassie R; Edlefsen, Paul T; Smedley, Jeremy; Klatt, Nichole R; Gale, Michael; Fuller, Deborah Heydenburg.
Afiliación
  • O'Connor MA; Department of Microbiology, University of Washington, Seattle, 98195, WA, USA.
  • Tisoncik-Go J; Washington National Primate Research Center, Seattle, 98121, WA, USA.
  • Lewis TB; Department of Immunology, University of Washington, Seattle, 98109, WA, USA.
  • Miller CJ; Center for Innate Immunity and Immune Disease (CIIID), University of Washington, Seattle, 98109, WA, USA.
  • Bratt D; Department of Microbiology, University of Washington, Seattle, 98195, WA, USA.
  • Moats CR; Washington National Primate Research Center, Seattle, 98121, WA, USA.
  • Edlefsen PT; Department of Pharmaceutics, University of Washington, Seattle, 98195, WA, USA.
  • Smedley J; Department of Pediatrics, University of Miami, Miami, 33136, FL, USA.
  • Klatt NR; Washington National Primate Research Center, Seattle, 98121, WA, USA.
  • Gale M; Washington National Primate Research Center, Seattle, 98121, WA, USA.
  • Fuller DH; Oregon National Primate Research Center, Hillsboro, 97006, OR, USA.
Nat Commun ; 9(1): 3371, 2018 08 22.
Article en En | MEDLINE | ID: mdl-30135445
The immunological and virological events that contribute to the establishment of Zika virus (ZIKV) infection in humans are unclear. Here, we show that robust cellular innate immune responses arising early in the blood and tissues in response to ZIKV infection are significantly stronger in males and correlate with increased viral persistence. In particular, early peripheral blood recruitment of plasmacytoid dendritic cells and higher production of monocyte chemoattractant protein (MCP-1) correspond with greater viral persistence and tissue dissemination. We also identify non-classical monocytes as primary in vivo targets of ZIKV infection in the blood and peripheral lymph node. These results demonstrate the potential differences in ZIKV pathogenesis between males and females and a key role for early cellular innate immune responses in the blood in viral dissemination and ZIKV pathogenesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus Zika / Inmunidad Innata / Macaca nemestrina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus Zika / Inmunidad Innata / Macaca nemestrina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido