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Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome.
Semick, Stephen A; Collado-Torres, Leonardo; Markunas, Christina A; Shin, Joo Heon; Deep-Soboslay, Amy; Tao, Ran; Huestis, Marilyn A; Bierut, Laura J; Maher, Brion S; Johnson, Eric O; Hyde, Thomas M; Weinberger, Daniel R; Hancock, Dana B; Kleinman, Joel E; Jaffe, Andrew E.
Afiliación
  • Semick SA; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA.
  • Collado-Torres L; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA.
  • Markunas CA; Center for Computational Biology, Johns Hopkins University, Baltimore, MD, 21205, USA.
  • Shin JH; Behavioral and Urban Health Program, Behavioral Health and Criminal Justice Division, RTI International, Research Triangle Park 3040 East Cornwallis Road, NC, 27709, USA.
  • Deep-Soboslay A; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA.
  • Tao R; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA.
  • Huestis MA; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA.
  • Bierut LJ; The Lambert Center for the Study of Medicinal Cannabis and Hemp, Institute of Emerging Health Professions, Thomas Jefferson University, Philadelphia, PA, USA.
  • Maher BS; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.
  • Johnson EO; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
  • Hyde TM; Fellow Program and Behavioral Health and Criminal Justice Division, RTI International, Research Triangle Park 3040 East Cornwallis Road, NC, 27709, USA.
  • Weinberger DR; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA.
  • Hancock DB; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.
  • Kleinman JE; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.
  • Jaffe AE; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA.
Mol Psychiatry ; 25(12): 3267-3277, 2020 12.
Article en En | MEDLINE | ID: mdl-30131587
Cigarette smoking during pregnancy is a major public health concern. While there are well-described consequences in early child development, there is very little known about the effects of maternal smoking on human cortical biology during prenatal life. We therefore performed a genome-wide differential gene expression analysis using RNA sequencing (RNA-seq) on prenatal (N = 33; 16 smoking-exposed) as well as adult (N = 207; 57 active smokers) human postmortem prefrontal cortices. Smoking exposure during the prenatal period was directly associated with differential expression of 14 genes; in contrast, during adulthood, despite a much larger sample size, only two genes showed significant differential expression (FDR < 10%). Moreover, 1,315 genes showed significantly different exposure effects between maternal smoking during pregnancy and direct exposure in adulthood (FDR < 10%)-these differences were largely driven by prenatal differences that were enriched for pathways previously implicated in addiction and synaptic function. Furthermore, prenatal and age-dependent differentially expressed genes were enriched for genes implicated in non-syndromic autism spectrum disorder (ASD) and were differentially expressed as a set between patients with ASD and controls in postmortem cortical regions. These results underscore the enhanced sensitivity to the biological effect of smoking exposure in the developing brain and offer insight into how maternal smoking during pregnancy affects gene expression in the prenatal human cortex. They also begin to address the relationship between in utero exposure to smoking and the heightened risks for the subsequent development of neuropsychiatric disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Trastorno del Espectro Autista Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Trastorno del Espectro Autista Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido