Binding conformation and determinants of a single-chain peptide antagonist at the relaxin-3 receptor RXFP3.

Haugaard-Kedström, Linda M; Lee, Han Siean; Jones, Maryon V; Song, Angela; Rathod, Vishaal; Hossain, Mohammed Akhter; Bathgate, Ross A D; Rosengren, K Johan

Haugaard-Kedström, Linda M; Lee, Han Siean; Jones, Maryon V; Song, Angela; Rathod, Vishaal; Hossain, Mohammed Akhter; Bathgate, Ross A D; Rosengren, K Johan.

Afiliación

Haugaard-Kedström LM; From the Faculty of Medicine, School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia.
Lee HS; the Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark, and.
Jones MV; From the Faculty of Medicine, School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia.
Song A; From the Faculty of Medicine, School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia.
Rathod V; From the Faculty of Medicine, School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia.
Hossain MA; From the Faculty of Medicine, School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia.
Bathgate RAD; the Florey Institute of Neuroscience and Mental Health.
Rosengren KJ; School of Chemistry, and.

J Biol Chem ; 293(41): 15765-15776, 2018 10 12.

Article en En | MEDLINE | ID: mdl-30131342

Asunto(s)

Péptidos/metabolismo; Receptores Acoplados a Proteínas G/metabolismo; Relaxina/metabolismo; Alanina/análogos & derivados; Alanina/síntesis química; Alanina/química; Alanina/metabolismo; Secuencia de Aminoácidos; Animales; Sitios de Unión; Células CHO; Cricetulus; Humanos; Péptidos/síntesis química; Péptidos/química; Unión Proteica; Conformación Proteica en Hélice alfa; Receptores Acoplados a Proteínas G/antagonistas & inhibidores; Receptores Acoplados a Proteínas G/química; Relaxina/síntesis química; Relaxina/química; Relación Estructura-Actividad

Palabras clave

G protein-coupled receptor (GPCR); R3 B1-22R; RXFP3; alanine scan; antagonist; neuropeptide; peptide conformation; peptide interaction; peptide stapling; relaxin-3

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Relaxina / Receptores Acoplados a Proteínas G Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2018 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos

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