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Gene therapy in cardiovascular diseases: A review of recent updates.
Gorabi, Armita M; Hajighasemi, Saeideh; Tafti, Hossein A; Soleimani, Masoud; Panahi, Yunes; Ganjali, Shiva; Sahebkar, Amirhossein.
Afiliación
  • Gorabi AM; Department of Basic and Clinical Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Hajighasemi S; Department of Medical Biotechnology, Faculty of Paramedicine, Qazvin University of Medical Sciences, Qazvin, Iran.
  • Tafti HA; Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Soleimani M; Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
  • Panahi Y; Pharmacotherapy Department, School of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Ganjali S; Department of Medical Biotechnology, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Sahebkar A; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
J Cell Biochem ; 119(12): 9645-9654, 2018 12.
Article en En | MEDLINE | ID: mdl-30129172
Gene therapy is considered as a promising approach for treating cardiac dysfunction. In this review, we evaluated the clinical trials assessing gene therapy in cardiovascular diseases (CVD) from 2000 to 2017. PubMed and ClinicalTrials.gov (only English language) were searched for clinical trials published between January 2000 and May 2017, using the search terms "gene transfer" OR "gene therapy" and "cardiovascular diseases" and related terms. The trials with sample size lower than 10 patients were excluded. Twenty-six clinical trials on human and animals, including 1543 patients were listed and evaluated. The sample size in 14 trials was lower than 100 patients and in seven trials lower than 20 patients. Eleven trials used plasmid DNA and eight trials used adenovirus, one study used plasmid DNA, adenovirus, and liposome. We detected that gene therapy was a safe approach and improved the symptoms of CVD; however, the effect of gene therapy on the cardiac dysfunction is controversial.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Terapia Genética / Vectores Genéticos Tipo de estudio: Systematic_reviews Límite: Animals / Humans Idioma: En Revista: J Cell Biochem Año: 2018 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Terapia Genética / Vectores Genéticos Tipo de estudio: Systematic_reviews Límite: Animals / Humans Idioma: En Revista: J Cell Biochem Año: 2018 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos