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Systematic analysis of transcriptomic profiles of COPD airway epithelium using next-generation sequencing and bioinformatics.
Chang, Wei-An; Tsai, Ming-Ju; Jian, Shu-Fang; Sheu, Chau-Chyun; Kuo, Po-Lin.
Afiliación
  • Chang WA; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, sheucc@gmail.com.
  • Tsai MJ; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, sheucc@gmail.com.
  • Jian SF; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, sheucc@gmail.com.
  • Sheu CC; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, sheucc@gmail.com.
  • Kuo PL; Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, sheucc@gmail.com.
Int J Chron Obstruct Pulmon Dis ; 13: 2387-2398, 2018.
Article en En | MEDLINE | ID: mdl-30127601
Introduction: COPD is a chronic inflammatory disease of lung. The inflammatory response in COPD is associated with neutrophils, macrophages, T lymphocytes, and bronchial epithelial cells, and occurs mainly in the small airway, leading to irreversible airflow limitation. Methods: In order to investigate the microRNA-mRNA interaction in the microenvironment of the COPD airway, we used next-generation sequencing and bioinformatics in this study. Results: We identified four genes with microRNA-mRNA interactions involved in COPD small-airway bronchial epithelial cells: NT5E, SDK1, TNS1, and PCDH7. Furthermore, miR6511a-5p-NT5E interaction was found to be involved in small-airway bronchial epithelial cells, large-airway bronchial epithelial cells, and alveolar macrophages. Conclusion: Our results showed that miR6511a-5p-NT5E interaction plays an important role in COPD, which might be associated with cell-cell contact, activation of leukocytes, activation of T lymphocytes, and cellular homeostasis. These findings provide new information for further investigations of the COPD microenvironment, and may help to develop new diagnostic or therapeutic strategies targeting the bronchial epithelium for COPD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadherinas / Moléculas de Adhesión Celular / 5'-Nucleotidasa / Biología Computacional / Enfermedad Pulmonar Obstructiva Crónica / Secuenciación de Nucleótidos de Alto Rendimiento / Tensinas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Int J Chron Obstruct Pulmon Dis Año: 2018 Tipo del documento: Article Pais de publicación: Nueva Zelanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadherinas / Moléculas de Adhesión Celular / 5'-Nucleotidasa / Biología Computacional / Enfermedad Pulmonar Obstructiva Crónica / Secuenciación de Nucleótidos de Alto Rendimiento / Tensinas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Int J Chron Obstruct Pulmon Dis Año: 2018 Tipo del documento: Article Pais de publicación: Nueva Zelanda