The Atxn7-overexpressing mice showed hyperactivity and impulsivity which were ameliorated by atomoxetine treatment: A possible animal model of the hyperactive-impulsive phenotype of ADHD.

Dela Peña, Irene Joy I; Botanas, Chrislean Jun; de la Peña, June Bryan; Custodio, Raly James; Dela Peña, Ike; Ryoo, Zae Young; Kim, Bung-Nyun; Ryu, Jong Hoon; Kim, Hee Jin; Cheong, Jae Hoon

Dela Peña, Irene Joy I; Botanas, Chrislean Jun; de la Peña, June Bryan; Custodio, Raly James; Dela Peña, Ike; Ryoo, Zae Young; Kim, Bung-Nyun; Ryu, Jong Hoon; Kim, Hee Jin; Cheong, Jae Hoon.

Afiliación

Dela Peña IJI; Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University, 815 Hwarang-ro, Nowon-gu, Seoul 139-742, Republic of Korea.
Botanas CJ; Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University, 815 Hwarang-ro, Nowon-gu, Seoul 139-742, Republic of Korea.
de la Peña JB; Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University, 815 Hwarang-ro, Nowon-gu, Seoul 139-742, Republic of Korea.
Custodio RJ; Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University, 815 Hwarang-ro, Nowon-gu, Seoul 139-742, Republic of Korea.
Dela Peña I; Department of Pharmaceutical and Administrative Sciences, Loma Linda University, CA 92350, USA.
Ryoo ZY; School of Life Science, BK21 Plus KNU Creative Bio Research Group, College of Natural Sciences, Kyungpook National University, Buk-ku, Daegu 41566, Republic of Korea.
Kim BN; Department of Research Planning, Mental Health Research Institute, National Center for Mental Health, Seoul, Republic of Korea.
Ryu JH; Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea; Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea.
Kim HJ; Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University, 815 Hwarang-ro, Nowon-gu, Seoul 139-742, Republic of Korea. Electronic address: hjkim@syu.ac.kr.
Cheong JH; Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University, 815 Hwarang-ro, Nowon-gu, Seoul 139-742, Republic of Korea. Electronic address: cheongjh@syu.ac.kr.

Prog Neuropsychopharmacol Biol Psychiatry ; 88: 311-319, 2019 01 10.

Article en En | MEDLINE | ID: mdl-30125623

Asunto(s)

Inhibidores de Captación Adrenérgica/uso terapéutico; Ataxina-7/metabolismo; Clorhidrato de Atomoxetina/uso terapéutico; Hipercinesia/tratamiento farmacológico; Hipercinesia/genética; Conducta Impulsiva/efectos de los fármacos; Animales; Ataxina-7/genética; Descuento por Demora/efectos de los fármacos; Proteínas Fluorescentes Verdes/genética; Proteínas Fluorescentes Verdes/metabolismo; Conducta Impulsiva/fisiología; Locomoción/efectos de los fármacos; Locomoción/genética; Aprendizaje por Laberinto/efectos de los fármacos; Ratones; Ratones Endogámicos C57BL; Ratones Transgénicos; ARN Mensajero; Receptores de Dopamina D1/genética; Receptores de Dopamina D1/metabolismo; Reconocimiento en Psicología/efectos de los fármacos; Prueba de Desempeño de Rotación con Aceleración Constante; Estadísticas no Paramétricas

Palabras clave

ADHD; Animal model; Atxn7; Hyperactivity; Impulsivity

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Captación Adrenérgica / Clorhidrato de Atomoxetina / Ataxina-7 / Hipercinesia / Conducta Impulsiva Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido

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