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Dual antiplatelet therapy pretreatment in IV thrombolysis for acute ischemic stroke.
Tsivgoulis, Georgios; Goyal, Nitin; Kerro, Ali; Katsanos, Aristeidis H; Krishnan, Rashi; Malhotra, Konark; Pandhi, Abhi; Duden, Peter; Deep, Aman; Shahripour, Reza Bavarsad; Bryndziar, Tomas; Nearing, Katherine; Chulpayev, Boris; Chang, Jason; Zand, Ramin; Alexandrov, Anne W; Alexandrov, Andrei V.
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  • Tsivgoulis G; From the Department of Neurology (G.T., N.G., A.K., R.K., A.P., P.D., A.D., R.B.S., T.B., K.N., B.C., J.C., R.Z., A.W.A., A.V.A.), University of Tennessee Health Science Center, Memphis; Second Department of Neurology (G.T., A.H.K.), Attikon University General Hospital, School of Medicine, National
  • Goyal N; From the Department of Neurology (G.T., N.G., A.K., R.K., A.P., P.D., A.D., R.B.S., T.B., K.N., B.C., J.C., R.Z., A.W.A., A.V.A.), University of Tennessee Health Science Center, Memphis; Second Department of Neurology (G.T., A.H.K.), Attikon University General Hospital, School of Medicine, National
  • Kerro A; From the Department of Neurology (G.T., N.G., A.K., R.K., A.P., P.D., A.D., R.B.S., T.B., K.N., B.C., J.C., R.Z., A.W.A., A.V.A.), University of Tennessee Health Science Center, Memphis; Second Department of Neurology (G.T., A.H.K.), Attikon University General Hospital, School of Medicine, National
  • Katsanos AH; From the Department of Neurology (G.T., N.G., A.K., R.K., A.P., P.D., A.D., R.B.S., T.B., K.N., B.C., J.C., R.Z., A.W.A., A.V.A.), University of Tennessee Health Science Center, Memphis; Second Department of Neurology (G.T., A.H.K.), Attikon University General Hospital, School of Medicine, National
  • Krishnan R; From the Department of Neurology (G.T., N.G., A.K., R.K., A.P., P.D., A.D., R.B.S., T.B., K.N., B.C., J.C., R.Z., A.W.A., A.V.A.), University of Tennessee Health Science Center, Memphis; Second Department of Neurology (G.T., A.H.K.), Attikon University General Hospital, School of Medicine, National
  • Malhotra K; From the Department of Neurology (G.T., N.G., A.K., R.K., A.P., P.D., A.D., R.B.S., T.B., K.N., B.C., J.C., R.Z., A.W.A., A.V.A.), University of Tennessee Health Science Center, Memphis; Second Department of Neurology (G.T., A.H.K.), Attikon University General Hospital, School of Medicine, National
  • Pandhi A; From the Department of Neurology (G.T., N.G., A.K., R.K., A.P., P.D., A.D., R.B.S., T.B., K.N., B.C., J.C., R.Z., A.W.A., A.V.A.), University of Tennessee Health Science Center, Memphis; Second Department of Neurology (G.T., A.H.K.), Attikon University General Hospital, School of Medicine, National
  • Duden P; From the Department of Neurology (G.T., N.G., A.K., R.K., A.P., P.D., A.D., R.B.S., T.B., K.N., B.C., J.C., R.Z., A.W.A., A.V.A.), University of Tennessee Health Science Center, Memphis; Second Department of Neurology (G.T., A.H.K.), Attikon University General Hospital, School of Medicine, National
  • Deep A; From the Department of Neurology (G.T., N.G., A.K., R.K., A.P., P.D., A.D., R.B.S., T.B., K.N., B.C., J.C., R.Z., A.W.A., A.V.A.), University of Tennessee Health Science Center, Memphis; Second Department of Neurology (G.T., A.H.K.), Attikon University General Hospital, School of Medicine, National
  • Shahripour RB; From the Department of Neurology (G.T., N.G., A.K., R.K., A.P., P.D., A.D., R.B.S., T.B., K.N., B.C., J.C., R.Z., A.W.A., A.V.A.), University of Tennessee Health Science Center, Memphis; Second Department of Neurology (G.T., A.H.K.), Attikon University General Hospital, School of Medicine, National
  • Bryndziar T; From the Department of Neurology (G.T., N.G., A.K., R.K., A.P., P.D., A.D., R.B.S., T.B., K.N., B.C., J.C., R.Z., A.W.A., A.V.A.), University of Tennessee Health Science Center, Memphis; Second Department of Neurology (G.T., A.H.K.), Attikon University General Hospital, School of Medicine, National
  • Nearing K; From the Department of Neurology (G.T., N.G., A.K., R.K., A.P., P.D., A.D., R.B.S., T.B., K.N., B.C., J.C., R.Z., A.W.A., A.V.A.), University of Tennessee Health Science Center, Memphis; Second Department of Neurology (G.T., A.H.K.), Attikon University General Hospital, School of Medicine, National
  • Chulpayev B; From the Department of Neurology (G.T., N.G., A.K., R.K., A.P., P.D., A.D., R.B.S., T.B., K.N., B.C., J.C., R.Z., A.W.A., A.V.A.), University of Tennessee Health Science Center, Memphis; Second Department of Neurology (G.T., A.H.K.), Attikon University General Hospital, School of Medicine, National
  • Chang J; From the Department of Neurology (G.T., N.G., A.K., R.K., A.P., P.D., A.D., R.B.S., T.B., K.N., B.C., J.C., R.Z., A.W.A., A.V.A.), University of Tennessee Health Science Center, Memphis; Second Department of Neurology (G.T., A.H.K.), Attikon University General Hospital, School of Medicine, National
  • Zand R; From the Department of Neurology (G.T., N.G., A.K., R.K., A.P., P.D., A.D., R.B.S., T.B., K.N., B.C., J.C., R.Z., A.W.A., A.V.A.), University of Tennessee Health Science Center, Memphis; Second Department of Neurology (G.T., A.H.K.), Attikon University General Hospital, School of Medicine, National
  • Alexandrov AW; From the Department of Neurology (G.T., N.G., A.K., R.K., A.P., P.D., A.D., R.B.S., T.B., K.N., B.C., J.C., R.Z., A.W.A., A.V.A.), University of Tennessee Health Science Center, Memphis; Second Department of Neurology (G.T., A.H.K.), Attikon University General Hospital, School of Medicine, National
  • Alexandrov AV; From the Department of Neurology (G.T., N.G., A.K., R.K., A.P., P.D., A.D., R.B.S., T.B., K.N., B.C., J.C., R.Z., A.W.A., A.V.A.), University of Tennessee Health Science Center, Memphis; Second Department of Neurology (G.T., A.H.K.), Attikon University General Hospital, School of Medicine, National
Neurology ; 91(11): e1067-e1076, 2018 09 11.
Article en En | MEDLINE | ID: mdl-30120131
OBJECTIVE: We sought to determine the safety and efficacy of IV thrombolysis (IVT) in acute ischemic stroke (AIS) patients with a history of dual antiplatelet therapy pretreatment (DAPP) in a prospective multicenter study. METHODS: We compared the following outcomes between DAPP+ and DAPP- IVT-treated patients before and after propensity score matching (PSM): symptomatic intracranial hemorrhage (sICH), asymptomatic intracranial hemorrhage, favorable functional outcome (modified Rankin Scale score 0-1), and 3-month mortality. RESULTS: Among 790 IVT patients, 58 (7%) were on DAPP before stroke (mean age 68 ± 13 years; 57% men; median NIH Stroke Scale score 8). DAPP+ patients were older with more risk factors compared to DAPP- patients. The rates of sICH were similar between groups (3.4% vs 3.2%). In multivariable analyses adjusting for potential confounders, DAPP was associated with higher odds of asymptomatic intracranial hemorrhage (odds ratio = 3.53, 95% confidence interval: 1.47-8.47; p = 0.005) but also with a higher likelihood of 3-month favorable functional outcome (odds ratio = 2.41, 95% confidence interval: 1.06-5.46; p = 0.035). After propensity score matching, 41 DAPP+ patients were matched to 82 DAPP- patients. The 2 groups did not differ in any of the baseline characteristics or safety and efficacy outcomes. CONCLUSIONS: DAPP is not associated with higher rates of sICH and 3-month mortality following IVT. DAPP should not be used as a reason to withhold IVT in otherwise eligible AIS candidates. CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that for IVT-treated patients with AIS, DAPP is not associated with a significantly higher risk of sICH. The study lacked the precision to exclude a potentially meaningful increase in sICH bleeding risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Agregación Plaquetaria / Terapia Trombolítica / Accidente Cerebrovascular / Hemorragias Intracraneales / Quimioterapia Combinada Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Neurology Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Agregación Plaquetaria / Terapia Trombolítica / Accidente Cerebrovascular / Hemorragias Intracraneales / Quimioterapia Combinada Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Neurology Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos