In vitro and in vivo pharmacokinetic and pharmacodynamic study of MBRI-001, a deuterium-substituted plinabulin derivative as a potent anti-cancer agent.

Ma, Mingxu; Zhao, Jianchun; Cheng, Hejuan; Deng, Mengyan; Ding, Zhongpeng; Hou, Yingwei; Li, Feng; Dou, Guifang; Li, Wenbao

Ma, Mingxu; Zhao, Jianchun; Cheng, Hejuan; Deng, Mengyan; Ding, Zhongpeng; Hou, Yingwei; Li, Feng; Dou, Guifang; Li, Wenbao.

Afiliación

Ma M; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Zhao J; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Marine Biomedical Research Institute of Qingdao, Qingdao 266071, China.
Cheng H; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Deng M; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Ding Z; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Hou Y; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Marine Biomedical Research Institute of Qingdao, Qingdao 266071, China.
Li F; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Marine Biomedical Research Institute of Qingdao, Qingdao 266071, China.
Dou G; Institute of Transfusion Medicine, Academy of Military Medical Sciences, Beijing 100850, China.
Li W; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Innovation Center for Marine Drug Screening and Evaluation, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China; Marine Biomedical Research Institute of Qingdao, Qingdao 266071, China.

Bioorg Med Chem ; 26(16): 4687-4692, 2018 09 01.

Article en En | MEDLINE | ID: mdl-30119994

Asunto(s)

Antineoplásicos/química; Dicetopiperazinas/química; Animales; Antineoplásicos/metabolismo; Antineoplásicos/farmacocinética; Antineoplásicos/uso terapéutico; Proteínas Sanguíneas/química; Proteínas Sanguíneas/metabolismo; Línea Celular Tumoral; Sistema Enzimático del Citocromo P-450/química; Sistema Enzimático del Citocromo P-450/metabolismo; Deuterio/química; Dicetopiperazinas/metabolismo; Dicetopiperazinas/farmacocinética; Dicetopiperazinas/uso terapéutico; Femenino; Semivida; Humanos; Concentración 50 Inhibidora; Masculino; Ratones; Ratones Endogámicos BALB C; Microsomas Hepáticos/metabolismo; Neoplasias/tratamiento farmacológico; Neoplasias/patología; Unión Proteica; Ratas; Ratas Wistar; Distribución Tisular

Palabras clave

Anticancer agent; Combination treatment; MBRI-001; Pharmacodynamics; Pharmacokinetics

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dicetopiperazinas / Antineoplásicos Límite: Animals / Female / Humans / Male Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google