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Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1.
Cha, Jong-Ho; Yang, Wen-Hao; Xia, Weiya; Wei, Yongkun; Chan, Li-Chuan; Lim, Seung-Oe; Li, Chia-Wei; Kim, Taewan; Chang, Shih-Shin; Lee, Heng-Huan; Hsu, Jennifer L; Wang, Hung-Ling; Kuo, Chu-Wei; Chang, Wei-Chao; Hadad, Sirwan; Purdie, Colin A; McCoy, Aaron M; Cai, Shirong; Tu, Yizheng; Litton, Jennifer K; Mittendorf, Elizabeth A; Moulder, Stacy L; Symmans, William F; Thompson, Alastair M; Piwnica-Worms, Helen; Chen, Chung-Hsuan; Khoo, Kay-Hooi; Hung, Mien-Chie.
Afiliación
  • Cha JH; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul 151-742, Korea.
  • Yang WH; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Xia W; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Wei Y; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Chan LC; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston, TX 77030, USA.
  • Lim SO; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Li CW; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Kim T; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Chang SS; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Lee HH; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Hsu JL; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 41
  • Wang HL; Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan.
  • Kuo CW; Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei 115, Taiwan.
  • Chang WC; Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan; Genomics Research Center, Academia Sinica, Nankang, Taipei 115, Taiwan.
  • Hadad S; Department of Surgery, University of Sheffield, Western Bank, Sheffield S10 2TN, UK.
  • Purdie CA; Department of Pathology, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
  • McCoy AM; Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Cai S; Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Tu Y; Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Litton JK; Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Mittendorf EA; Department of Breast Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Moulder SL; Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Symmans WF; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Thompson AM; Department of Breast Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Piwnica-Worms H; Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston, TX 77030, USA.
  • Chen CH; Genomics Research Center, Academia Sinica, Nankang, Taipei 115, Taiwan.
  • Khoo KH; Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei 115, Taiwan.
  • Hung MC; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston, TX 77030, USA; Graduate Institute of Biomedical Sciences and Center for Molecular Medicine
Mol Cell ; 71(4): 606-620.e7, 2018 08 16.
Article en En | MEDLINE | ID: mdl-30118680
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación Neoplásica de la Expresión Génica / Antígeno B7-H1 / Antígeno CTLA-4 / Hipoglucemiantes / Metformina / Antineoplásicos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación Neoplásica de la Expresión Génica / Antígeno B7-H1 / Antígeno CTLA-4 / Hipoglucemiantes / Metformina / Antineoplásicos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos