Integrated imaging of [<sup>11</sup>C]-PBR28 PET, MR diffusion and magnetic resonance spectroscopy <sup>1</sup>H-MRS in amyotrophic lateral sclerosis.

Ratai, Eva-Maria; Alshikho, Mohamad J; Zürcher, Nicole R; Loggia, Marco L; Cebulla, Catherine L; Cernasov, Paul; Reynolds, Beverly; Fish, Jennifer; Seth, Raghav; Babu, Suma; Paganoni, Sabrina; Hooker, Jacob M; Atassi, Nazem

Integrated imaging of [¹¹C]-PBR28 PET, MR diffusion and magnetic resonance spectroscopy ¹H-MRS in amyotrophic lateral sclerosis.

Ratai, Eva-Maria; Alshikho, Mohamad J; Zürcher, Nicole R; Loggia, Marco L; Cebulla, Catherine L; Cernasov, Paul; Reynolds, Beverly; Fish, Jennifer; Seth, Raghav; Babu, Suma; Paganoni, Sabrina; Hooker, Jacob M; Atassi, Nazem.

Afiliación

Ratai EM; A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; Department of Radiology, Neuroradiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: eratai@m
Alshikho MJ; A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; Neurological Clinical Research Institute (NCRI), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Elec
Zürcher NR; A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Electronic address: zurcher@nmr.mgh.harvard.edu.
Loggia ML; A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Electronic address: marco@nmr.mgh.harvard.edu.
Cebulla CL; Neurological Clinical Research Institute (NCRI), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: ccebulla@mgh.harvard.edu.
Cernasov P; Neurological Clinical Research Institute (NCRI), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: paul.cernasov@unc.edu.
Reynolds B; Neurological Clinical Research Institute (NCRI), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: bvreynolds@mgh.harvard.edu.
Fish J; Neurological Clinical Research Institute (NCRI), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Seth R; A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Babu S; Neurological Clinical Research Institute (NCRI), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: sbabu@mgh.harvard.edu.
Paganoni S; Neurological Clinical Research Institute (NCRI), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: spaganoni@mgh.harvard.edu.
Hooker JM; A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Electronic address: hooker@nmr.mgh.harvard.edu.
Atassi N; Neurological Clinical Research Institute (NCRI), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: natassi@mgh.harvard.edu.

Neuroimage Clin ; 20: 357-364, 2018.

Article en En | MEDLINE | ID: mdl-30112276

Asunto(s)

Acetamidas; Esclerosis Amiotrófica Lateral/diagnóstico por imagen; Radioisótopos de Carbono; Imagen de Difusión Tensora/métodos; Tomografía de Emisión de Positrones/métodos; Espectroscopía de Protones por Resonancia Magnética/métodos; Piridinas; Adulto; Esclerosis Amiotrófica Lateral/metabolismo; Femenino; Humanos; Espectroscopía de Resonancia Magnética/métodos; Masculino; Persona de Mediana Edad; Imagen Multimodal/métodos

Palabras clave

1H-MRS; 1H-MRS, proton magnetic resonance spectroscopy; ALS, amyotrophic lateral sclerosis; ALSFRS-R, revised ALS functional rating scale; Amyotrophic lateral sclerosis; Cr, creatine; DTI; DTI, diffusion tensor imaging; FA, fractional anisotropy; Glial activation; MEMPRAGE, multi-echo magnetization prepared rapid acquisition gradient echo; NAA, N-acetylaspartate; PBR, peripheral benzodiazepine receptor.; PET; PRESS, point-resolved spectroscopy; SUV, standardized uptake value; SUVR, standardized uptake value normalized to whole brain mean; TSPO, translocator protein; UMNB, upper motor neuron burden; VOI, volume of interest; [11C]-PBR28; mI, myo-inositol

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridinas / Radioisótopos de Carbono / Tomografía de Emisión de Positrones / Imagen de Difusión Tensora / Espectroscopía de Protones por Resonancia Magnética / Esclerosis Amiotrófica Lateral / Acetamidas Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Neuroimage Clin Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos

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