Elucidation of fluorine's impact on pKa and in vitro Pgp-mediated efflux for a series of PDE9 inhibitors.

Fjelbye, Kasper; Marigo, Mauro; Clausen, Rasmus P; Jørgensen, Erling B; Christoffersen, Claus T; Juhl, Karsten

Elucidation of fluorine's impact on pK_a and in vitro Pgp-mediated efflux for a series of PDE9 inhibitors.

Fjelbye, Kasper; Marigo, Mauro; Clausen, Rasmus P; Jørgensen, Erling B; Christoffersen, Claus T; Juhl, Karsten.

Afiliación

Fjelbye K; H. Lundbeck A/S , Ottiliavej 9 , 2500 Valby , Denmark . Email: kaju@lundbeck.com.
Marigo M; Department of Drug Design and Pharmacology , Faculty of Health and Medical Sciences , University of Copenhagen , 2 Universitetsparken , 2100 , Copenhagen , Denmark.
Clausen RP; H. Lundbeck A/S , Ottiliavej 9 , 2500 Valby , Denmark . Email: kaju@lundbeck.com.
Jørgensen EB; Department of Drug Design and Pharmacology , Faculty of Health and Medical Sciences , University of Copenhagen , 2 Universitetsparken , 2100 , Copenhagen , Denmark.
Christoffersen CT; H. Lundbeck A/S , Ottiliavej 9 , 2500 Valby , Denmark . Email: kaju@lundbeck.com.
Juhl K; H. Lundbeck A/S , Ottiliavej 9 , 2500 Valby , Denmark . Email: kaju@lundbeck.com.

Medchemcomm ; 9(5): 893-896, 2018 May 01.

Article en En | MEDLINE | ID: mdl-30108979

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Medchemcomm Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido

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