Your browser doesn't support javascript.
loading
Noninvasive scoring systems predict hepatic and extra-hepatic cancers in patients with nonalcoholic fatty liver disease.
Peleg, Noam; Sneh Arbib, Orly; Issachar, Assaf; Cohen-Naftaly, Michal; Braun, Marius; Shlomai, Amir.
Afiliación
  • Peleg N; Department of Medicine D, Rabin Medical Center, Beilinson hospital, Petach-Tikva, Israel.
  • Sneh Arbib O; The Liver Institute, Rabin Medical Center, Beilinson hospital, Petach-Tikva, Israel.
  • Issachar A; Department of Medicine D, Rabin Medical Center, Beilinson hospital, Petach-Tikva, Israel.
  • Cohen-Naftaly M; The Liver Institute, Rabin Medical Center, Beilinson hospital, Petach-Tikva, Israel.
  • Braun M; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Shlomai A; The Liver Institute, Rabin Medical Center, Beilinson hospital, Petach-Tikva, Israel.
PLoS One ; 13(8): e0202393, 2018.
Article en En | MEDLINE | ID: mdl-30106985
BACKGROUND: Liver fibrosis predicts liver-related morbidity and mortality in patients with non-alcoholic fatty liver disease (NAFLD). Non-invasive scores correlate with the degree of liver fibrosis in these patients. AIMS AND METHODS: To investigate the accuracy of noninvasive scoring systems in predicting long-term outcomes and cancer incidence of patients with NAFLD, we performed a single-center retrospective study of patients with biopsy proven NAFLD. Mean follow up period was 100 months. Outcomes included liver-related complications, hospitalizations, overall mortality and the development of any malignancies. RESULTS: 32 patients had advanced fibrosis (F3-F4) per biopsy at baseline and 121 patients had mild to moderate fibrosis (F0-F2). Both advanced histologic fibrosis stage as well as higher non-invasive scores predicted repeated hospitalizations and longer hospitalization stays. In a multivariate analysis, liver fibrosis (p = 0.002), FIB-4 score (p<0.001), NFS (p<0.001) but not APRI score (p = 0.07) were predictors of overall mortality, and the occurrence of malignancies was associated with higher APRI (p<0.001), FIB-4 (p<0.001) and NFS (p = 0.008) scores, but not with advanced fibrosis, as determined by liver biopsy (p = 0.105). CONCLUSIONS: In NAFLD patients, noninvasive scoring systems are good predictors of morbidity and mortality and may have an additive value in predicting the development of hepatic and extra-hepatic cancers.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad del Hígado Graso no Alcohólico / Cirrosis Hepática / Neoplasias Hepáticas Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad del Hígado Graso no Alcohólico / Cirrosis Hepática / Neoplasias Hepáticas Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos