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CXCR4-directed theranostics in oncology and inflammation.
Kircher, Malte; Herhaus, Peter; Schottelius, Margret; Buck, Andreas K; Werner, Rudolf A; Wester, Hans-Jürgen; Keller, Ulrich; Lapa, Constantin.
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  • Kircher M; Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany.
  • Herhaus P; Internal Medicine III, Hematology and Medical Oncology, Technische Universität München, Munich, Germany.
  • Schottelius M; Pharmaceutical Radiochemistry, Technische Universität München, Munich, Germany.
  • Buck AK; Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany.
  • Werner RA; Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany.
  • Wester HJ; Division of Nuclear Medicine and Molecular Imaging, Johns Hopkins University School of Medicine, Baltimore, USA.
  • Keller U; Pharmaceutical Radiochemistry, Technische Universität München, Munich, Germany.
  • Lapa C; Internal Medicine III, Hematology and Medical Oncology, Technische Universität München, Munich, Germany.
Ann Nucl Med ; 32(8): 503-511, 2018 Oct.
Article en En | MEDLINE | ID: mdl-30105558
Given its prominent role in inflammation and cancer biology, the C-X-C motif chemokine receptor 4 (CXCR4) has gained a lot of attention in the recent years. This review gives a short overview of the physiology and pathology of chemokines and chemokine receptors and then focuses on the current experience of targeting CXCR4, using radiolabeled receptor ligands suitable for positron emission tomography (PET) imaging, in both hematologic and solid malignancy as well as in inflammatory conditions. Additionally, CXCR4-directed endoradiotherapy (ERT) as a new treatment option is discussed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores CXCR4 / Terapia Molecular Dirigida / Inflamación / Neoplasias Límite: Animals / Humans Idioma: En Revista: Ann Nucl Med Asunto de la revista: MEDICINA NUCLEAR Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores CXCR4 / Terapia Molecular Dirigida / Inflamación / Neoplasias Límite: Animals / Humans Idioma: En Revista: Ann Nucl Med Asunto de la revista: MEDICINA NUCLEAR Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Japón