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Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures.
Lee, Joo Sang; Adler, Lital; Karathia, Hiren; Carmel, Narin; Rabinovich, Shiran; Auslander, Noam; Keshet, Rom; Stettner, Noa; Silberman, Alon; Agemy, Lilach; Helbling, Daniel; Eilam, Raya; Sun, Qin; Brandis, Alexander; Malitsky, Sergey; Itkin, Maxim; Weiss, Hila; Pinto, Sivan; Kalaora, Shelly; Levy, Ronen; Barnea, Eilon; Admon, Arie; Dimmock, David; Stern-Ginossar, Noam; Scherz, Avigdor; Nagamani, Sandesh C S; Unda, Miguel; Wilson, David M; Elhasid, Ronit; Carracedo, Arkaitz; Samuels, Yardena; Hannenhalli, Sridhar; Ruppin, Eytan; Erez, Ayelet.
Afiliación
  • Lee JS; Cancer Data Science Lab, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Center for Bioinformatics and Computational Biology, University of Maryland Institute for Advanced Computer Studies, Department of Computer Science, University of Maryland, College Park, MD 20
  • Adler L; Department of Biological Regulation, Weizmann Institute of Science, 7610001 Rehovot, Israel.
  • Karathia H; Center for Bioinformatics and Computational Biology, University of Maryland Institute for Advanced Computer Studies, Department of Computer Science, University of Maryland, College Park, MD 20742, USA.
  • Carmel N; Department of Biological Regulation, Weizmann Institute of Science, 7610001 Rehovot, Israel.
  • Rabinovich S; Department of Biological Regulation, Weizmann Institute of Science, 7610001 Rehovot, Israel.
  • Auslander N; Cancer Data Science Lab, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Center for Bioinformatics and Computational Biology, University of Maryland Institute for Advanced Computer Studies, Department of Computer Science, University of Maryland, College Park, MD 20
  • Keshet R; Department of Biological Regulation, Weizmann Institute of Science, 7610001 Rehovot, Israel.
  • Stettner N; Department of Biological Regulation, Weizmann Institute of Science, 7610001 Rehovot, Israel; Department of Veterinary Resources, Weizmann Institute of Science, 7610001 Rehovot, Israel.
  • Silberman A; Department of Biological Regulation, Weizmann Institute of Science, 7610001 Rehovot, Israel.
  • Agemy L; Department of Plant and Environmental Science, Weizmann Institute of Science, 7610001 Rehovot, Israel.
  • Helbling D; Envision Genomics, Huntsville, AL 35806, USA.
  • Eilam R; Department of Veterinary Resources, Weizmann Institute of Science, 7610001 Rehovot, Israel.
  • Sun Q; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
  • Brandis A; Life Sciences Core Facilities, Weizmann Institute of Science, 7610001 Rehovot, Israel.
  • Malitsky S; Life Sciences Core Facilities, Weizmann Institute of Science, 7610001 Rehovot, Israel.
  • Itkin M; Life Sciences Core Facilities, Weizmann Institute of Science, 7610001 Rehovot, Israel.
  • Weiss H; Department of Biological Regulation, Weizmann Institute of Science, 7610001 Rehovot, Israel.
  • Pinto S; Department of Biological Regulation, Weizmann Institute of Science, 7610001 Rehovot, Israel.
  • Kalaora S; Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel.
  • Levy R; Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel.
  • Barnea E; Faculty of Biology, Technion - Israel Institute of Technology, 3200003 Haifa, Israel.
  • Admon A; Faculty of Biology, Technion - Israel Institute of Technology, 3200003 Haifa, Israel.
  • Dimmock D; Rady Children's Institute for Genomic Medicine, San Diego, CA 92123, USA.
  • Stern-Ginossar N; Department of Molecular Genetics, Weizmann Institute of Science, 7610001 Rehovot, Israel.
  • Scherz A; Department of Veterinary Resources, Weizmann Institute of Science, 7610001 Rehovot, Israel.
  • Nagamani SCS; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Texas Children's Hospital, Houston, TX 77030, USA.
  • Unda M; Department of Urology, Basurto University Hospital, 48013 Bilbao, Spain; CIBERONC, Madrid, Spain.
  • Wilson DM; Laboratory of Molecular Gerontology, National Institute on Aging, Intramural Research Program, NIH, 251 Bayview Blvd., Baltimore, MD 21224, USA.
  • Elhasid R; Sackler Faculty of Medicine, Department of Pediatric Hemato Oncology, Sourasky Medical Center, Tel Aviv University, 6997801 Tel Aviv, Israel.
  • Carracedo A; CIBERONC, Madrid, Spain; CIC bioGUNE, Bizkaia Technology Park, 801 Building, 48160 Derio, Spain; Ikerbasque, Basque Foundation for Science, Bilbao, Spain; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Bilbao, Spain.
  • Samuels Y; Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel.
  • Hannenhalli S; Center for Bioinformatics and Computational Biology, University of Maryland Institute for Advanced Computer Studies, Department of Computer Science, University of Maryland, College Park, MD 20742, USA.
  • Ruppin E; Cancer Data Science Lab, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Center for Bioinformatics and Computational Biology, University of Maryland Institute for Advanced Computer Studies, Department of Computer Science, University of Maryland, College Park, MD 20
  • Erez A; Department of Biological Regulation, Weizmann Institute of Science, 7610001 Rehovot, Israel. Electronic address: eyruppin@gmail.com.
Cell ; 174(6): 1559-1570.e22, 2018 09 06.
Article en En | MEDLINE | ID: mdl-30100185
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Urea / Genómica / Metabolómica / Neoplasias Límite: Animals / Female / Humans Idioma: En Revista: Cell Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Urea / Genómica / Metabolómica / Neoplasias Límite: Animals / Female / Humans Idioma: En Revista: Cell Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos