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Pupillary response: cognitive effort for breast cancer survivors.
Myers, Jamie S; Kahya, Melike; Mitchell, Melissa; Dai, Junqiang; He, Jianghua; Moon, Sanghee; Hamilton, Kevin; Valla, Mary; O'Dea, Anne; Klemp, Jennifer; Kurylo, Monica; Akinwuntan, Abiodun; Devos, Hannes.
Afiliación
  • Myers JS; Office of Grants and Research, University of Kansas School of Nursing, MS 4043, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA. jmyers@kumc.edu.
  • Kahya M; Department of Physical Therapy and Rehabilitation Science, University of Kansas School of Health Professions, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA.
  • Mitchell M; Department of Radiation Oncology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA.
  • Dai J; Department of Biostatistics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA.
  • He J; Department of Biostatistics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA.
  • Moon S; Department of Physical Therapy and Rehabilitation Science, University of Kansas School of Health Professions, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA.
  • Hamilton K; Department of Physical Therapy and Rehabilitation Science, University of Kansas School of Health Professions, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA.
  • Valla M; North Kansas City Hospital, 2750 Clay Edwards Drive, North Kansas City, MO, 64116, USA.
  • O'Dea A; Department of Medical Oncology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA.
  • Klemp J; University of Kansas Cancer Center, 2650 Shawnee Mission Pkwy, Westwood, KS, 66205, USA.
  • Kurylo M; Department of Psychiatry & Behavioral Sciences, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA.
  • Akinwuntan A; Department of Physical Therapy and Rehabilitation Science, University of Kansas School of Health Professions, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA.
  • Devos H; Department of Physical Therapy and Rehabilitation Science, University of Kansas School of Health Professions, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA.
Support Care Cancer ; 27(3): 1121-1128, 2019 Mar.
Article en En | MEDLINE | ID: mdl-30097791
PURPOSE: The purpose of this cross-sectional comparative pilot study was to evaluate cognitive effort, indexed by pupillary response (PR), for breast cancer survivors (BCS) with complaints of cognitive dysfunction following chemotherapy. STUDY AIMS: Compare the cognitive effort employed by BCS to healthy controls (HC) during neuropsychological tests (NPT) for memory, sustained attention, verbal fluency, visuospatial ability, processing speed and executive function; and Investigate the relationship between PR-indexed cognitive effort and participants' self-report of cognitive function. METHODS: Self-report of cognitive function was collected from 23 BCS and 23 HC. PR was measured during NPT. Independent two-sample t tests or Wilcoxon rank sum tests were used to compare group scores. Between-group effect size (Cohen's d) was calculated for each outcome. Correlation between mean self-report scores and PR values, as well as 95% confidence intervals, was calculated. RESULTS: No group differences were demonstrated for NPT performance. BCS reported more issues with cognitive function than HC (p < .0001). A group effect for BCS was seen with PR-indexed cognitive effort for components of most NPT (p < .05). PR was correlated with most self-report measures of cognitive function (r = 0.33-0.45). CONCLUSIONS: PR sensitivity to cognitive effort across a variety of NPT and correlation with self-report of cognitive function was demonstrated. The portability, affordability, and "real-time" aspects of PR are attractive for potential use in the clinic setting to assess cognitive function. A larger study is needed to confirm these results. Prospective investigation of PR in BCS is needed to demonstrate sensitivity to cognitive function changes over time.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pupila / Cognición / Disfunción Cognitiva / Supervivientes de Cáncer / Pruebas Neuropsicológicas Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Support Care Cancer Asunto de la revista: NEOPLASIAS / SERVICOS DE SAUDE Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pupila / Cognición / Disfunción Cognitiva / Supervivientes de Cáncer / Pruebas Neuropsicológicas Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Support Care Cancer Asunto de la revista: NEOPLASIAS / SERVICOS DE SAUDE Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania