1,25-Dihydroxyvitamin D3 attenuates disease severity and induces synoviocyte apoptosis in a concentration-dependent manner in rats with adjuvant-induced arthritis by inactivating the NF-&#954;B signaling pathway.

Sun, Hua-Qiang; Yan, Dong; Wang, Qin-Nan; Meng, Hong-Zheng; Zhang, Ye-Yong; Yin, Lu-Xu; Yan, Xin-Feng; Li, Shu-Feng

1,25-Dihydroxyvitamin D3 attenuates disease severity and induces synoviocyte apoptosis in a concentration-dependent manner in rats with adjuvant-induced arthritis by inactivating the NF-κB signaling pathway.

Sun, Hua-Qiang; Yan, Dong; Wang, Qin-Nan; Meng, Hong-Zheng; Zhang, Ye-Yong; Yin, Lu-Xu; Yan, Xin-Feng; Li, Shu-Feng.

Afiliación

Sun HQ; Department of Bone and Joint Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, No. 16766, Jingshi Road, Jinan, 250014, Shandong, People's Republic of China.
Yan D; Department of Bone and Joint Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, No. 16766, Jingshi Road, Jinan, 250014, Shandong, People's Republic of China.
Wang QN; Department of Orthopedics, Weihai Hospital of Traditional Chinese Medicine, Weihai, 264200, People's Republic of China.
Meng HZ; Department of Bone and Joint Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, No. 16766, Jingshi Road, Jinan, 250014, Shandong, People's Republic of China.
Zhang YY; Department of Bone and Joint Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, No. 16766, Jingshi Road, Jinan, 250014, Shandong, People's Republic of China.
Yin LX; Department of Bone and Joint Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, No. 16766, Jingshi Road, Jinan, 250014, Shandong, People's Republic of China.
Yan XF; Department of Bone and Joint Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, No. 16766, Jingshi Road, Jinan, 250014, Shandong, People's Republic of China. shq8365138@126.com.
Li SF; Department of Bone and Joint Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, No. 16766, Jingshi Road, Jinan, 250014, Shandong, People's Republic of China. shu_fengli@163.com.

J Bone Miner Metab ; 37(3): 430-440, 2019 May.

Article en En | MEDLINE | ID: mdl-30097709

Asunto(s)

Apoptosis/efectos de los fármacos; Artritis Experimental/tratamiento farmacológico; Artritis Experimental/patología; FN-kappa B/metabolismo; Índice de Severidad de la Enfermedad; Transducción de Señal; Sinoviocitos/patología; Vitamina D/análogos & derivados; Animales; Artritis Experimental/diagnóstico por imagen; Artritis Experimental/metabolismo; Artritis Reumatoide/tratamiento farmacológico; Proliferación Celular/efectos de los fármacos; Células Cultivadas; Regulación hacia Abajo/efectos de los fármacos; Hiperplasia; Inflamación/patología; Mediadores de Inflamación/metabolismo; Masculino; Ratas Sprague-Dawley; Transducción de Señal/efectos de los fármacos; Membrana Sinovial/efectos de los fármacos; Membrana Sinovial/patología; Sinoviocitos/efectos de los fármacos; Sinoviocitos/metabolismo; Vitamina D/farmacología; Vitamina D/uso terapéutico

Palabras clave

1,25(OH)2D3; Adjuvant-induced arthritis; NF-κB signaling pathway; Rheumatoid arthritis; Synoviocyte

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Experimental / Vitamina D / Índice de Severidad de la Enfermedad / Transducción de Señal / FN-kappa B / Apoptosis / Sinoviocitos Límite: Animals Idioma: En Revista: J Bone Miner Metab Asunto de la revista: METABOLISMO Año: 2019 Tipo del documento: Article Pais de publicación: Japón

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